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Updated: Jun 27, 2025
Author Spotlight: THP-1 Macrophage Response to LPS/ATP — Unveiling the Pyroptosis, Apoptosis, and Necroptosis Spectrum
Published on: May 3, 2024
The Role of Pyroptosis in Coronary Heart Disease
Yinyin Qiu1, Liping Meng1, Yangbo Xing1
1Department of Cardiology, Shaoxing People's Hospital, Shaoxing City, Zhejiang Province, China.
Insights
Pyroptosis, a programmed cell death, is increasingly linked to cardiovascular diseases like coronary heart disease. Understanding pyroptosis mechanisms offers new therapeutic targets for heart conditions.
Area of Science:
- Cardiovascular Biology
- Cellular Biology
- Immunology
Background:
- Cardiovascular diseases (CVDs), including coronary heart disease (CHD), represent a growing global health burden.
- Pyroptosis, an inflammasome-mediated programmed cell death, is characterized by inflammation and cellular damage.
- Emerging evidence implicates pyroptosis in the pathophysiology of CHD.
Purpose of the Study:
- To review the role of pyroptosis in the development of coronary heart disease.
- To summarize pyroptosis's contribution to specific cardiovascular conditions.
- To highlight potential therapeutic strategies targeting pyroptosis for heart diseases.
Main Methods:
- Literature review of pyroptosis and its role in cardiovascular diseases.
- Analysis of cellular mechanisms underlying pyroptosis in atherosclerosis and heart failure.
- Identification of therapeutic targets and drugs related to pyroptosis.
Main Results:
- Pyroptosis contributes to atherosclerosis by affecting endothelial cells, macrophages, and vascular smooth muscle cells.
- Inflammatory cytokine release during pyroptosis exacerbates cardiovascular damage.
- Pyroptosis is implicated in angina pectoris, myocardial infarction, ischemia-reperfusion injury, and heart failure.
Conclusions:
- Pyroptosis is a critical factor in the pathogenesis of various cardiovascular diseases.
- Targeting pyroptosis pathways presents a promising avenue for novel cardiovascular therapies.
- Further research into pyroptosis mechanisms can lead to improved treatments for heart conditions.
Abstract:
The incidence and mortality of cardiovascular diseases, of which coronary heart disease (CHD) is a significant cardiovascular burden, are on the rise. Pyroptosis as an incipient programmed cell death mediated by inflammasomes can sense cytoplasmic contamination or interference and is typically marked by intracellular swelling, plasma membrane blistering and intense inflammatory cytokine release. As research on pyroptosis continues to progress, there is mounting evidence that pyroptosis is a vital participant in the pathophysiological basis of CHD. Atherosclerosis is the major pathophysiological basis of CHD and involves pyroptosis of endothelial cells, macrophages, vascular smooth muscle cells, and other immune cells, often in association with the release of pro-inflammatory factors. When cardiomyocytes are damaged, it will eventually lead to heart failure. Previous studies have covered that pyroptosis plays a critical role in CHD. In this review, we describe the properties of pyroptosis, summarize its contribution and related targets to diseases involving angina pectoris, myocardial infarction, myocardial ischemia in perfusion injury and heart failure, and highlight potential drugs for different heart diseases.
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