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Updated: Jun 27, 2025
07:25
A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
Published on: March 6, 2018
13.1K
[Prostate cancer - a disease in transformation]
1professor, överläkare, Prostatacancercentrum, Sahlgrenska universitetssjukhuset, Göteborg.
Lakartidningen
|April 25, 2024
Summary
Advances in prostate cancer (prostate-specific antigen) screening and treatment have halved mortality for men under 85. Improved diagnostics reduce overdiagnosis, enhancing patient care and research through national registries.
Area of Science:
- Oncology
- Urology
- Public Health
Background:
- The introduction of prostate-specific antigen (PSA) testing and prostate biopsies in the 1990s led to increased diagnoses of localized prostate cancer and radical treatments.
- Significant advancements in diagnostic methods and a deeper understanding of tumor biology have been crucial in refining prostate cancer care.
Purpose of the Study:
- To provide an overview of contemporary prostate cancer care, highlighting key advancements and their impact.
- To discuss the evolution of diagnostic and treatment strategies in prostate cancer management.
- To emphasize the role of national registries and patient organizations in improving prostate cancer outcomes.
Main Methods:
- Review of contemporary prostate cancer care practices and advancements.
- Analysis of the impact of new diagnostic tools and treatments on patient outcomes.
- Examination of the role and evolution of the National Prostate Cancer Register of Sweden (NPCR).
Main Results:
- The incidence of localized prostate cancer and radical treatment use rose significantly following the introduction of PSA testing and biopsies.
- Improved diagnostics and understanding of tumor biology are now mitigating overdiagnosis and enabling organized screening.
- Age-standardized prostate cancer mortality in men under 85 has been halved due to more effective treatments and earlier diagnosis.
Conclusions:
- Contemporary prostate cancer care has seen dramatic improvements, leading to reduced mortality.
- Organized screening, advanced diagnostics, and effective treatments are key to better patient outcomes.
- National registries like the NPCR are vital for supporting clinical care and research, alongside the growing influence of patient organizations.
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