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Practical Application of Multivendor MRI-Based R2* Mapping for Liver Iron Quantification at 1.5 T and 3.0 T.

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Vendor R2* maps can reliably quantify liver iron concentration (LIC) below 13 mg/g. This study validates vendor R2* reconstructions against centralized methods for broad clinical use.

Keywords:
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Area of Science:

  • Magnetic Resonance Imaging (MRI)
  • Medical Physics
  • Radiology

Background:

  • Multicenter, multivendor MRI-based R2* vs. liver iron concentration (LIC) calibrations (MCMV calibrations) aim to standardize LIC quantification.
  • Applicability of MCMV calibrations with vendor-provided R2* maps remains unclear due to reliance on centralized offline reconstruction.

Purpose of the Study:

  • To determine R2* ranges of agreement between centralized and three MRI vendors' R2* reconstructions.
  • To assess the reliability of vendor-provided R2* maps for LIC quantification.

Main Methods:

  • Prospective study involving 207 subjects with suspected iron overload.
  • Standardized multiecho spoiled gradient echo and multiple spin-echo sequences used at 1.5T and 3.0T.
  • Bland-Altman analysis, linear regression, and ANOVA F tests used to assess agreement and reproducibility.

Main Results:

  • Upper limits of R2* agreement varied by vendor and field strength (e.g., ~330 s⁻¹ for Siemens at 1.5T, ~800 s⁻¹ for Philips at 3.0T).
  • Vendor R2*-LIC calibrations showed high reproducibility and agreed with MCMV calibrations within R2* ranges of agreement.

Conclusions:

  • Vendor-provided R2* maps can be reliably used for LIC quantification (< approx. 8-13 mg/g) with MCMV calibrations.
  • Findings support broad clinical dissemination of R2*-based LIC quantification using vendor software.