Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Transmission-based Precautions II: Airborne and Protective Environment

Transmission-based Precautions II: Airborne and Protective Environment

Transmission-based precautions are for patients infected or suspected to be infected (or colonized) with organisms posing a significant risk to others. The transmission precautions include airborne and protective environment precautions.
Airborne precautions:
Use airborne precautions when treating patients known or suspected to have diseases that spread through the air—for example, tuberculosis or measles. These organisms are present in smaller droplets expelled by an infected person and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Short term heart transplant outcomes with heart organ procurement services.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation·2026

Same author

Racial Disparities in Cutaneous Melanoma Mortality: A Systematic Review and Meta-Analysis.

Journal of racial and ethnic health disparities·2026

Same author

"ID-ing" the value: how are orthopaedic infectious disease physicians compensated for their time? A national survey.

Journal of bone and joint infection·2026

Same author

Erratum: Challenging cases in infection prevention and control: proceedings from SHEA Spring 2025 - CORRIGENDUM.

Antimicrobial stewardship & healthcare epidemiology : ASHE·2026

Same author

Sex-related differences in pain following posterior spinal fusion for adolescent idiopathic scoliosis: a retrospective cohort study.

Spine deformity·2026

Same author

Antibiotic Duration after Debridement and Implant Retention for Early Postoperative Spinal Implant Infections: A Multicenter Cohort Study.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2026

Search research articles

Related Experiment Video

Updated: Jun 27, 2025

Author Spotlight: 3D Movement Assessment of Maxillary Posterior Teeth in Clear Aligner Treatment

Author Spotlight: 3D Movement Assessment of Maxillary Posterior Teeth in Clear Aligner Treatment

Published on: February 23, 2024

Static Versus Articulating Spacer: Does Infectious Pathogen Type Affect Treatment Success?

Caitlin Grant¹, Jerry Chang¹, Emily Poehlein²

¹Duke University School of Medicine, Durham, NC, USA.

Clinical Orthopaedics and Related Research

|April 25, 2024

Summary

Static and articulating antibiotic spacers show no significant difference in preventing periprosthetic joint infection (PJI) treatment failure. Pathogen type also did not influence the effectiveness of spacer choice in this study.

More Related Videos

Studying Orthodontic Tooth Movement in Mice

Studying Orthodontic Tooth Movement in Mice

Published on: August 2, 2024

Author Spotlight: Advancing Research on Candida albicans Biofilm-Associated Prosthetic Joint Infections

Author Spotlight: Advancing Research on Candida albicans Biofilm-Associated Prosthetic Joint Infections

Published on: February 2, 2024

Related Experiment Videos

Last Updated: Jun 27, 2025

Author Spotlight: 3D Movement Assessment of Maxillary Posterior Teeth in Clear Aligner Treatment

Author Spotlight: 3D Movement Assessment of Maxillary Posterior Teeth in Clear Aligner Treatment

Published on: February 23, 2024

Studying Orthodontic Tooth Movement in Mice

Studying Orthodontic Tooth Movement in Mice

Published on: August 2, 2024

Author Spotlight: Advancing Research on Candida albicans Biofilm-Associated Prosthetic Joint Infections

Author Spotlight: Advancing Research on Candida albicans Biofilm-Associated Prosthetic Joint Infections

Published on: February 2, 2024

Area of Science:

Orthopedic surgery
Infectious disease
Biomaterials science

Background:

Periprosthetic joint infection (PJI) treatment often involves antibiotic-containing spacers, but persistent infections occur.
Few studies assess infection control from spacer implantation or consider pathogen type interactions.
Defining treatment failure consistently is crucial for evaluating spacer efficacy.

Purpose of the Study:

To compare failure-free survival between static and articulating antibiotic spacers for PJI.
To determine if pathogen type modifies the relationship between spacer type and treatment success.
To investigate outcomes from the time of spacer implantation.

Main Methods:

A cohort of 246 patients with knee PJI treated with static or articulating spacers was analyzed.
Failure-free survival was defined as no reoperation, reinfection, or chronic antibiotic use.
Cox proportional hazards models assessed spacer type and pathogen type interactions on outcomes.

Main Results:

No significant difference in failure-free survival was observed between static and articulating spacers (HR 1.45, p=0.09).
No significant interaction was found between spacer type and pathogen type (staphylococcal vs. nonstaphylococcal, difficult-to-treat vs. not) for failure-free survival.
Hazard ratios for static spacers varied by pathogen type but did not reach statistical significance for interaction.

Conclusions:

Spacer type (static vs. articulating) does not appear to significantly impact failure-free survival in PJI treatment.
Pathogen type does not seem to be a critical factor in choosing between static or articulating spacers.
Future research should focus on patient-specific factors influencing surgeon decisions for spacer selection.