Related Experiment Video
Updated: Jun 27, 2025
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Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
Published on: May 2, 2025
144
Post-translational modifications in kidney diseases and associated cardiovascular risk
Heidi Noels1,2,3, Vera Jankowski4,5, Stefan J Schunk6
1Institute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, Aachen, Germany. hnoels@ukaachen.de.
Nature Reviews. Nephrology
|April 25, 2024
Summary
Patients with chronic kidney disease (CKD) experience higher cardiovascular risk due to unique kidney disease mechanisms. Altered protein modifications in CKD contribute to disease progression and may serve as diagnostic biomarkers.
Area of Science:
- Nephrology
- Cardiovascular Medicine
- Biochemistry
Background:
- Patients with chronic kidney disease (CKD) exhibit elevated cardiovascular risk compared to the general population.
- This increased risk is partly attributed to mechanisms specific to kidney disease.
Purpose of the Study:
- To explore the role of post-translational protein modifications in CKD pathogenesis.
- To identify potential diagnostic biomarkers and therapeutic targets related to these modifications.
Main Methods:
- The study reviews existing evidence on post-translational modifications in CKD.
- Focuses on both non-enzymatic (oxidation, glycation, carbamylation, guanidinylation) and enzymatic (glycosylation, ubiquitination, acetylation, methylation) modifications.
Main Results:
- CKD is associated with increased oxidative stress and uremic solutes, promoting aberrant protein modifications.
- These modifications alter protein and lipoprotein structure/function, contributing to inflammation, fibrosis, vascular damage, and prothrombotic states in CKD.
Conclusions:
- Post-translational protein modifications are implicated in CKD progression and cardiovascular risk.
- These modifications represent potential diagnostic biomarkers and therapeutic targets for CKD management.
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