Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

520
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
520
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

4.0K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.0K
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

68.2K
Overview
68.2K
Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

326
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
326
Tissue Transplantation01:24

Tissue Transplantation

360
Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
360
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

7.6K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Oncolytic virus OH2 induces PD-L1 upregulation via NF-κB signaling and synergizes with anti-PD-L1 therapy in prostate cancer through a targeted extracellular vesicle delivery system.

Journal for immunotherapy of cancer·2026
Same author

TRIM29 drives ulcerative colitis by disrupting lipid metabolism via lysosomal dysfunction: a multi-omics and experimental study.

Frontiers in immunology·2026
Same author

Targeting the HSP60/p53 Axis with Extracellular Vesicle-Delivered siRNA Reprograms Glycolysis in Prostate Cancer.

International journal of biological sciences·2026
Same author

Programmable molecular microscopy: CRISPR/Cas fluorescent probes revolutionizing spatiotemporal genomic imaging.

Theranostics·2025
Same author

Efficacy of oncolytic virus in the treatment of intermediate-to-advanced solid tumors: a systematic review and meta-analysis.

Journal of virology·2025
Same author

From Plant Based Therapy to Plant-Derived Vesicle-Like Nanoparticles for Cancer Treatment: Past, Present and Future.

International journal of nanomedicine·2025
Same journal

Autologous transplant versus matched sibling donor transplant in intermediate-risk AML in CR1 with no detectable MRD: a biological assignment comparative study.

Experimental hematology & oncology·2026
Same journal

Role of methionine metabolism in cancer: recent advances in molecular mechanisms and therapeutic implications.

Experimental hematology & oncology·2026
Same journal

Advances in antibody-drug conjugates in cancer: latest updates from the 2026 AACR annual meeting.

Experimental hematology & oncology·2026
Same journal

Targeting the cancer metabolism-immunity interface: update and perspectives.

Experimental hematology & oncology·2026
Same journal

Leveraging multimodal cancer immunotherapy to amplify the efficacy of oncolytic viruses.

Experimental hematology & oncology·2026
Same journal

Personalized chemotherapy guidance using patient-derived scaffolds from peritoneal colorectal metastases.

Experimental hematology & oncology·2026
See all related articles

Related Experiment Video

Updated: Jun 27, 2025

Generation of CAR T Cells for Adoptive Therapy in the Context of Glioblastoma Standard of Care
12:55

Generation of CAR T Cells for Adoptive Therapy in the Context of Glioblastoma Standard of Care

Published on: February 16, 2015

21.4K

Enhanced cellular therapy: revolutionizing adoptive cellular therapy.

Meng-Yao Xu1, Na Zeng1, Chen-Qian Liu1

  • 1Department and Institute of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No.1095 Jiefang Avenue, Wuhan, 430030, China.

Experimental Hematology & Oncology
|April 25, 2024
PubMed
Summary
This summary is machine-generated.

Enhanced cellular therapy improves adoptive cellular therapy (ACT) by using drugs or biotechnology to boost immune cell effectiveness. Strategies include overcoming the tumor microenvironment and improving cell targeting for better cancer treatment outcomes.

Keywords:
Adoptive cellular therapyEnhanced cellular therapyImmune checkpoint inhibitorImmunotherapyOncolytic virusPROTAC

More Related Videos

Manufacturing Chimeric Antigen Receptor CAR T Cells for Adoptive Immunotherapy
06:51

Manufacturing Chimeric Antigen Receptor CAR T Cells for Adoptive Immunotherapy

Published on: December 17, 2019

15.0K
HLA-Ig Based Artificial Antigen Presenting Cells for Efficient ex vivo Expansion of Human CTL
07:18

HLA-Ig Based Artificial Antigen Presenting Cells for Efficient ex vivo Expansion of Human CTL

Published on: April 11, 2011

15.4K

Related Experiment Videos

Last Updated: Jun 27, 2025

Generation of CAR T Cells for Adoptive Therapy in the Context of Glioblastoma Standard of Care
12:55

Generation of CAR T Cells for Adoptive Therapy in the Context of Glioblastoma Standard of Care

Published on: February 16, 2015

21.4K
Manufacturing Chimeric Antigen Receptor CAR T Cells for Adoptive Immunotherapy
06:51

Manufacturing Chimeric Antigen Receptor CAR T Cells for Adoptive Immunotherapy

Published on: December 17, 2019

15.0K
HLA-Ig Based Artificial Antigen Presenting Cells for Efficient ex vivo Expansion of Human CTL
07:18

HLA-Ig Based Artificial Antigen Presenting Cells for Efficient ex vivo Expansion of Human CTL

Published on: April 11, 2011

15.4K

Area of Science:

  • Oncology
  • Immunology
  • Biotechnology

Background:

  • Cellular therapy offers a foundation for advanced treatments.
  • Enhanced cellular therapy aims to improve the efficacy of adoptive cellular therapy (ACT).

Purpose of the Study:

  • To comprehensively summarize the mechanisms, current status, and clinical applications of enhanced cellular therapy.
  • To describe potential improvements to adoptive cellular therapy.

Main Methods:

  • Utilizing drugs and biotechnology to enhance immune cells for ACT.
  • Employing immune checkpoint inhibitors (ICIs), small molecule inhibitors, immunomodulatory factors, proteolysis targeting chimera (PROTAC), and oncolytic viruses (OV).
  • Genetic engineering to express cytokines/receptors and designing multi-antigen chimeric antigen receptors (CARs).

Main Results:

  • Overcoming the inhibitory tumor microenvironment (TME) by blocking immune checkpoints enhances ACT efficacy.
  • Improved migration and infiltration of adoptive cells via cytokine expression or addition.
  • Enhanced tumor cell recognition and antigen release through CARs and OVs.
  • PROTAC technology offers safety switches and degradation of immunosuppressive factors.

Conclusions:

  • Enhanced cellular therapy represents a significant advancement in cancer treatment.
  • Various strategies can be employed to boost the safety and efficacy of adoptive cellular therapy.