Determination of moxifloxacin in milk using a ratiometric fluorescent sensor based on Ag-MOF@curcumin

Moxifloxacin (MFX) has attracted increasing public concern recently, and the development of a simple and effective analysis method has become a research focus. In this work, a simple, sensitive and ratiometric fluorescent sensor based on Ag-MOF@curcumin was designed and investigated. Ag-MOF@curcumin displays emission at 410 nm and 475 nm under excitation at 330 nm. When MFX is added, a new emission peak appears at 500 nm, and the F₅₀₀/F₄₁₀ ratio has a linear relationship with the MFX concentration in the range 0-35 μmol L^-1 with a low LOD (0.179 μmol L^-1). Finally, the developed sensor was used for the determination of MFX in milk. This work provides an excellent fluorescent sensor for highly selective and rapid detection of MFX residues.