Related Experiment Video
Updated: May 6, 2026
Single Cell Measurements of Vacuolar Rupture Caused by Intracellular Pathogens
Published on: June 12, 2013
Detection of OXA-181 Carbapenemase in Shigella flexneri
Abstract:
We report the detection of OXA-181 carbapenemase in an azithromycin-resistant Shigella spp. bacteria in an immunocompromised patient. The emergence of OXA-181 in Shigella spp. bacteria raises concerns about the global dissemination of carbapenem resistance in Enterobacterales and its implications for the treatment of infections caused by Shigella bacteria.
Insights
A carbapenemase (OXA-181) was found in azithromycin-resistant Shigella bacteria from an immunocompromised patient. This discovery highlights the growing threat of carbapenem resistance in Enterobacterales globally.
Area of Science:
- Microbiology
- Infectious Diseases
- Antimicrobial Resistance
Background:
- Shigella species are significant causes of bacterial dysentery worldwide.
- Carbapenem resistance is a growing public health concern, particularly within the Enterobacterales order.
- Azithromycin resistance in Shigella complicates treatment options.
Observation:
- OXA-181 carbapenemase, a marker of carbapenem resistance, was detected in Shigella spp.
- The bacteria also exhibited azithromycin resistance.
- The isolate was identified in an immunocompromised patient, a vulnerable population.
Findings:
- This is the first report of OXA-181 carbapenemase in Shigella species.
- The co-occurrence of azithromycin and carbapenem resistance mechanisms in Shigella is concerning.
Implications:
- The findings suggest a potential for global dissemination of carbapenem-resistant Shigella.
- This resistance poses a significant challenge for treating Shigella infections, especially in resource-limited settings.
- Enhanced surveillance for carbapenem resistance in Shigella is crucial.
