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Related Concept Videos

Dementia01:30

Dementia

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Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
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Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
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Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
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Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
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Ischemic heart disease occurs when the heart's blood supply dwindles, causing an ominous lack of oxygen and nutrients. This deficiency, stemming from reduced or obstructed blood flow, spells danger, leading to heart muscle damage and dysfunction.
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Related Experiment Video

Updated: Jun 27, 2025

Using Retinal Imaging to Study Dementia
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The relationship between atherosclerosis and dementia.

Jana Janoutová1, Ondřej Machaczka2,3, Martina Kovalová2,3,4

  • 1Department of Public Health, Faculty of Medicine and Dentistry, Palacky University Olomouc, Olomouc, Czech Republic.

Central European Journal of Public Health
|April 26, 2024
PubMed
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Atherosclerosis significantly increases dementia risk. This study found that lower education, physical labor, and less activity are linked to cognitive impairment and atherosclerosis, highlighting shared risk factors.

Keywords:
atherosclerosisdementiaepidemiologypreventionrisk factors

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Area of Science:

  • Neurology
  • Epidemiology
  • Cardiovascular Science

Background:

  • Atherosclerosis is a significant risk factor for cognitive impairment.
  • Vascular cognitive impairment is associated with reduced quality of life and survival.
  • Understanding shared risk factors is crucial for prevention strategies.

Purpose of the Study:

  • To confirm the hypothesis that atherosclerosis influences cognitive impairment and increases dementia risk.
  • To analyze epidemiological data on risk factors for atherosclerosis and dementia.
  • To investigate the relationship between lifestyle, cardiovascular health, and cognitive decline.

Main Methods:

  • An epidemiological case-control study was conducted.
  • Data were collected via questionnaire survey from 877 subjects (target 920).
  • Participants were grouped based on clinical examination for atherosclerosis and dementia.

Main Results:

  • Subjects with both dementia and atherosclerosis had significantly lower education levels (45.2%) compared to those without dementia (16%).
  • Lower physical activity was more prevalent in dementia groups (47.2%-54.4%) versus non-dementia groups (19.6%-25.8%).
  • Coronary heart disease was reported more frequently in dementia patients (33.95%) than in those without dementia (16.05%).

Conclusions:

  • Shared risk factors contribute to the development of both atherosclerosis and dementia.
  • Cognitive impairment, especially vascular, is linked to poorer outcomes.
  • Interventions targeting shared risk factors may mitigate both conditions.