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An Injectable and Drug-loaded Supramolecular Hydrogel for Local Catheter Injection into the Pig Heart

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Injectable hydrogels based on alginates grafted with LCST side-chains of different chemistry.

L Barbier¹, P Pipart¹, M Vahdati²

¹Soft Matter Sciences and Engineering, ESPCI Paris, PSL University, Sorbonne University, CNRS, F-75005 Paris, France.

Carbohydrate Polymers

|April 26, 2024

Summary

This study developed injectable thermoresponsive hydrogels by grafting polymers onto alginates. These smart hydrogels exhibit controlled gelation and drug release at body temperature, offering potential for biomedical applications.

Keywords:

Alginate Gelation Hydrogel Injectable Thermo-responsive polymers

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Published on: June 7, 2024

Area of Science:

Polymer Science
Materials Science
Biomaterials Engineering

Background:

Thermoresponsive polymers are crucial for developing smart hydrogels with tunable properties.
Alginate-based hydrogels offer biocompatibility and versatility for drug delivery and tissue engineering.
Understanding the relationship between polymer structure and hydrogel properties is essential for optimizing performance.

Purpose of the Study:

To synthesize and characterize thermoassociating copolymers based on alginates and temperature-responsive polymers.
To investigate the sol/gel transition and gel properties of these novel hydrogels.
To evaluate the injectability, swelling, and molecular release characteristics for potential biomedical applications.

Main Methods:

Grafting of poly(N-isopropylacrylamide), poly(di(ethylene glycol)methacrylate), and poly(ethylene oxide-co-propylene oxide) onto alginates.
Comprehensive characterization using rheology, calorimetry, Nuclear Magnetic Resonance (NMR), and Small-Angle X-ray Scattering (SAXS).
Assessment of adhesiveness, injectability, gel swelling, and molecular release in a physiological environment.

Main Results:

Established a homologous series of thermoassociating copolymers with controlled grafting.
Identified key parameters governing the sol/gel transition, including macromolecular entanglement and responsive sticker fraction.
Demonstrated that steady shear experiments predict injection forces, and rapid gelation at 37°C controls molecular release.

Conclusions:

Developed injectable thermoresponsive hydrogels with tunable properties based on alginate scaffolds.
Provided quantitative guidelines for designing hydrogels with predictable gelation and release profiles.
Highlighted the potential of these materials for advanced drug delivery and regenerative medicine applications.