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The Aftermath of COVID-19: Exploring the Long-Term Effects on Organ Systems
Maryam Golzardi1, Altijana Hromić-Jahjefendić1, Jasmin Šutković1
1Department of Genetics and Bioengineering, Faculty of Engineering and Natural Sciences, International University of Sarajevo, Hrasnicka Cesta 15, 71000 Sarajevo, Bosnia and Herzegovina.
Biomedicines
|April 27, 2024
Summary
Post-acute sequelae of SARS-CoV-2 infection (PASC), or long-COVID, affects millions globally, impacting multiple organ systems. Early infection intensity correlates with PASC severity and symptom development.
Area of Science:
- Medical Research
- Infectious Diseases
- Public Health
Background:
- Post-acute sequelae of SARS-CoV-2 infection (PASC) affects millions worldwide, with 10-12% of vaccinated individuals experiencing complications.
- PASC prevalence is higher in hospitalized COVID-19 patients (50-70%) and linked to initial infection severity.
Purpose of the Study:
- To summarize the diverse health complications associated with PASC across multiple organ systems.
- To highlight the broad physiological impact and public health implications of long-COVID.
Main Methods:
- Review of existing studies and reported patient diagnoses related to PASC.
- Analysis of documented symptoms and conditions affecting various organ systems.
Main Results:
- PASC manifests with neuropsychiatric, neurological, cardiovascular (myocarditis, pericarditis), and hematological (thrombotic endothelialitis, hypercoagulability) complications.
- Respiratory issues (chest pain, breathlessness), immune dysfunctions, renal problems (fibrosis, sepsis), endocrine disorders (diabetes, infertility), gastrointestinal disturbances, and skin conditions are also reported.
- Long-COVID impacts multiple organ systems, increasing the risk for various chronic diseases and conditions.
Conclusions:
- Long-COVID is a complex, multidimensional syndrome with significant public health consequences.
- Comprehensive medical management and further research into PASC's underlying mechanisms and long-term effects are crucial.
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