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Rating L-DOPA-Induced Dyskinesias in the Unilaterally 6-OHDA-Lesioned Rat Model of Parkinson's Disease
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[Nocturia in Parkinson's disease]
A A Pilipovich1, O V Vorob'eva1, S A Makarov1
1Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.
Zhurnal Nevrologii I Psikhiatrii Imeni S.S. Korsakova
|April 27, 2024
Summary
Nocturia is a common symptom in Parkinson's disease (PD), affecting quality of life. It worsens with disease progression and is linked to non-dopamine-related symptoms, suggesting a shared underlying cause.
Area of Science:
- Neurology
- Urology
Context:
- Parkinson's disease (PD) is a neurodegenerative disorder affecting motor function.
- Nocturia, or nighttime urination, is a prevalent but often overlooked symptom in PD patients.
- Understanding nocturia's relationship with PD clinical features is crucial for improving patient care.
Purpose:
- To evaluate the occurrence of nocturia in Parkinson's disease patients.
- To investigate the association between nocturia and various clinical characteristics of PD, including disease severity and dopaminergic therapy.
- To identify predictors of nocturia in PD.
Summary:
- Nocturia was present in 93 out of 113 Parkinson's disease patients, correlating with age, disease severity (Hoehn and Yahr stage), and UPDRS scores.
- Nocturia showed significant associations with quality of life (PDQ-39), cognitive function (FAB), mood (BDI, STAI), autonomic dysfunction (NMSQuest), and gastrointestinal issues.
- Dopaminergic therapy did not significantly impact nocturia severity; depression, supine blood pressure, constipation, and postural instability were identified as key predictors.
Impact:
- Nocturia is a highly prevalent urological symptom in early-stage Parkinson's disease, significantly impacting patients' quality of life.
- The strong association of nocturia with non-dopaminergic symptoms suggests a common pathophysiological basis, potentially involving polytransmitter imbalance.
- Findings highlight the need to address nocturia as a significant comorbidity in PD management, independent of dopaminergic treatment.
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