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Parkinson's Disease: Treatment01:24

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Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
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Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
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Related Experiment Video

Updated: Jun 27, 2025

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[Nocturia in Parkinson's disease].

A A Pilipovich1, O V Vorob'eva1, S A Makarov1

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Zhurnal Nevrologii I Psikhiatrii Imeni S.S. Korsakova
|April 27, 2024
PubMed
Summary

Nocturia is a common symptom in Parkinson's disease (PD), affecting quality of life. It worsens with disease progression and is linked to non-dopamine-related symptoms, suggesting a shared underlying cause.

Keywords:
Parkinson’s diseaseautonomic disordersnocturianon-motor disordersurological dysfunction

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Area of Science:

  • Neurology
  • Urology

Context:

  • Parkinson's disease (PD) is a neurodegenerative disorder affecting motor function.
  • Nocturia, or nighttime urination, is a prevalent but often overlooked symptom in PD patients.
  • Understanding nocturia's relationship with PD clinical features is crucial for improving patient care.

Purpose:

  • To evaluate the occurrence of nocturia in Parkinson's disease patients.
  • To investigate the association between nocturia and various clinical characteristics of PD, including disease severity and dopaminergic therapy.
  • To identify predictors of nocturia in PD.

Summary:

  • Nocturia was present in 93 out of 113 Parkinson's disease patients, correlating with age, disease severity (Hoehn and Yahr stage), and UPDRS scores.
  • Nocturia showed significant associations with quality of life (PDQ-39), cognitive function (FAB), mood (BDI, STAI), autonomic dysfunction (NMSQuest), and gastrointestinal issues.
  • Dopaminergic therapy did not significantly impact nocturia severity; depression, supine blood pressure, constipation, and postural instability were identified as key predictors.

Impact:

  • Nocturia is a highly prevalent urological symptom in early-stage Parkinson's disease, significantly impacting patients' quality of life.
  • The strong association of nocturia with non-dopaminergic symptoms suggests a common pathophysiological basis, potentially involving polytransmitter imbalance.
  • Findings highlight the need to address nocturia as a significant comorbidity in PD management, independent of dopaminergic treatment.