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Related Experiment Video

Updated: Jun 27, 2025

Optocardiography and Electrophysiology Studies of Ex Vivo Langendorff-perfused Hearts
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Optocardiography and Electrophysiology Studies of Ex Vivo Langendorff-perfused Hearts

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Ex Vivo Working Porcine Heart Model.

Henry Pigot1, Kristian Soltesz2, Stig Steen3

  • 1Department of Automatic Control, Lund University, Lund, Sweden. henry.pigot@control.lth.se.

Methods in Molecular Biology (Clifton, N.J.)
|April 27, 2024
PubMed
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Ex vivo working porcine heart models offer a valuable platform for studying heart function and disease, mimicking human physiology. This research details model components and introduces an advanced device for more accurate afterload simulation.

Area of Science:

  • Cardiovascular Physiology
  • Surgical Research
  • Transplantation Science

Background:

  • Ex vivo working porcine heart models simulate human cardiac function outside the body.
  • Porcine hearts share anatomical and physiological similarities with human hearts.
  • These models aid in studying cardiac disease and assessing donor heart viability.

Purpose of the Study:

  • To provide a comprehensive discussion of ex vivo working porcine heart model components.
  • To explore challenges and historical methods in emulating cardiac afterload.
  • To introduce an actively controlled afterload device for enhanced experimental accuracy.

Main Methods:

  • Detailed examination of perfusate, preload, and afterload in the model.
  • Historical review of afterload modeling techniques and limitations.
Keywords:
Cardiac afterloadCyber-physiological systemsEx situ heart perfusionEx vivo heart evaluationEx vivo heart perfusionFunctional heart assessmentFunctional heart evaluationHeart transplantationIsolated heart preparationWorking porcine heart

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Related Experiment Videos

Last Updated: Jun 27, 2025

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Published on: November 7, 2019

12.9K
An Isolated Working Heart System for Large Animal Models
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  • Introduction and application of an actively controlled afterload device.

    • Main Results:

    • Identification of challenges in accurately replicating cardiac afterload.
    • Demonstration of an actively controlled device for dynamic pressure adjustment.
    • Establishment of a comprehensive experimental protocol.

    Conclusions:

    • Ex vivo working porcine heart models are crucial for cardiac research and transplantation.
    • Accurate afterload emulation is critical for model validity.
    • The proposed actively controlled afterload device improves experimental precision.