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Association of Matrix Metalloproteinase-9 Genotypes With Lung Cancer Risk in Taiwan
Li-Hsiou Chen1,2,3, Yuh-Feng Tsai4,5, Wen-Tzu Wu6
1Division of Chest Medicine, Department of Internal Medicine, Taichung Tzu Chi Hospital, Taichung, Taiwan, R.O.C.
Background/Aim:
Matrix metalloproteinase-9 (MMP-9) expression is upregulated in various diseases, including lung cancer. However, the role of MMP-9 genotype in lung cancer susceptibility remains uncertain. This study aimed to clarify the contribution of MMP-9 promoter rs3918242 genotypes to the risk of lung cancer in Taiwan.
Materials And Methods:
The MMP-9 rs3918242 genotypes of 358 lung cancer patients and 716 healthy controls were determined using polymerase chain reaction-restriction fragment length polymorphism methodology.
Results:
Individuals carrying the variant CT or TT genotype of MMP-9 rs3918242 did not demonstrate an increased risk of lung cancer compared to wild-type CC carriers [odds ratio (OR)=1.11 and 1.85, 95% confidence interval (95%CI)=0.82-1.48 and 0.91-3.76; p=0.5541 and 0.1280, respectively]. Moreover, individuals carrying the T allele did not show a higher lung cancer risk compared to those with the C allele (OR=1.21, 95%CI=0.95-1.54, p=0.1444). However, a significant association was observed between the MMP-9 rs3918242 TT genotype and lung cancer risk among non-smokers (OR=5.48, 95%CI=1.31-22.89, p=0.0181).
Conclusion:
The presence of the TT genotype for MMP-9 rs3918242 may indicate an elevated risk of lung cancer among non-smokers.
Insights
The matrix metalloproteinase-9 (MMP-9) rs3918242 TT genotype is linked to increased lung cancer risk specifically in non-smokers. Overall lung cancer risk was not significantly associated with this MMP-9 genotype or allele.
Area of Science:
- Genetics and Genomics
- Oncology
- Molecular Biology
Background:
- Matrix metalloproteinase-9 (MMP-9) is implicated in various diseases, including lung cancer.
- The specific contribution of MMP-9 genetic variations to lung cancer susceptibility requires further investigation.
Purpose of the Study:
- To investigate the association between the MMP-9 promoter rs3918242 polymorphism and lung cancer risk in the Taiwanese population.
- To clarify the role of MMP-9 genotypes in lung cancer susceptibility.
Main Methods:
- Genotyping of the MMP-9 rs3918242 polymorphism was performed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).
- The study included 358 lung cancer patients and 716 healthy controls.
Main Results:
- No significant association was found between MMP-9 rs3918242 genotypes (CT or TT) or allele (T) and overall lung cancer risk.
- A significant association was observed between the MMP-9 rs3918242 TT genotype and an elevated risk of lung cancer among non-smokers (OR=5.48, p=0.0181).
Conclusions:
- The MMP-9 rs3918242 TT genotype may be a risk factor for lung cancer in non-smokers.
- Further research is warranted to elucidate the specific mechanisms underlying this association.
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