Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Tribute to Dr. Frank Beier (1965-2025).

Osteoarthritis and cartilage·2026
Same author

Sex Hormones Attenuate Pro-Inflammatory Gene Expression in Nucleus Pulposus and Annulus Fibrosus Cells in a Cell-Type Specific Manner.

JOR spine·2026
Same author

Tribute to Dr. Frank Beier (1965-2025).

Osteoarthritis and cartilage·2025
Same author

Tribute to Dr. Frank Beier (1965-2025).

Osteoarthritis and cartilage·2025
Same author

Identifying challenges and enablers to engaging patients in preclinical laboratory research: an interview study.

Research involvement and engagement·2025
Same author

Severe osteoarthritis in aged PANX3 knockout mice: implications for a novel primary osteoarthritis model.

JBMR plus·2025

Related Experiment Video

Updated: Jun 27, 2025

Author Spotlight: Enhancing Rheumatoid Arthritis Research Through HR-pQCT Imaging Analysis
06:31

Author Spotlight: Enhancing Rheumatoid Arthritis Research Through HR-pQCT Imaging Analysis

Published on: October 6, 2023

2.1K

Spatiotemporal changes in imaging features associated with diffuse idiopathic skeletal hyperostosis (DISH).

Dale E Fournier1,2, Michele C Battie2,3, Cheryle A Séguin4,5

  • 1Health and Rehabilitation Sciences (Physical Therapy), Faculty of Health Sciences, The University of Western Ontario, London, ON, Canada.

RMD Open
|April 27, 2024
PubMed
Summary

Diffuse idiopathic skeletal hyperostosis (DISH) progression shows distinct imaging changes over time. Early stages involve new spinal segment involvement, while advanced stages feature increased bridging, with nodules appearing early.

Keywords:
ArthritisClassificationOsteoarthritis

More Related Videos

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

19.9K
Standardized Histomorphometric Evaluation of Osteoarthritis in a Surgical Mouse Model
07:32

Standardized Histomorphometric Evaluation of Osteoarthritis in a Surgical Mouse Model

Published on: May 6, 2020

12.1K

Related Experiment Videos

Last Updated: Jun 27, 2025

Author Spotlight: Enhancing Rheumatoid Arthritis Research Through HR-pQCT Imaging Analysis
06:31

Author Spotlight: Enhancing Rheumatoid Arthritis Research Through HR-pQCT Imaging Analysis

Published on: October 6, 2023

2.1K
Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

19.9K
Standardized Histomorphometric Evaluation of Osteoarthritis in a Surgical Mouse Model
07:32

Standardized Histomorphometric Evaluation of Osteoarthritis in a Surgical Mouse Model

Published on: May 6, 2020

12.1K

Area of Science:

  • Radiology
  • Orthopedics
  • Rheumatology

Background:

  • Diffuse idiopathic skeletal hyperostosis (DISH) is a common condition affecting spinal ligaments.
  • Understanding DISH progression is crucial for diagnosis and management.

Purpose of the Study:

  • To characterize the spatiotemporal features of disease progression in diffuse idiopathic skeletal hyperostosis (DISH).
  • To analyze disease progression across early-phase DISH, advanced DISH, and non-DISH cohorts using serial CT scans.

Main Methods:

  • Retrospective study using the Rochester Epidemiology Project.
  • Analysis of serial thoracic spine CT scans from 157 individuals (83 female, 74 male) over an average of 2.7 years.
  • Evaluation of ectopic bridging and disease status changes over time.

Main Results:

  • Over 15% of individuals experienced diagnostic changes along the DISH continuum.
  • Early-phase DISH showed new motion segment involvement (approx. 2.1 years).
  • Advanced DISH exhibited increased complete bridging (approx. 2.6-2.9 years) and early-phase nodules.

Conclusions:

  • This study provides the first characterization of spatiotemporal features across all DISH phases.
  • DISH progression is characterized by distinct features at different disease stages.
  • Early spinal ligament and intervertebral disc mineralized nodules may play a key role in DISH pathogenesis.