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Updated: Jun 27, 2025

Identification of Footprints of RNA:Protein Complexes via RNA Immunoprecipitation in Tandem Followed by Sequencing RIPiT-Seq
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Decapping NAD-RNAs: TIR domain-containing proteins stand out for specificity

Dechang Cao1

  • 1Germplasm Bank of Wild Species, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Yunnan 650201, China.

Trends in Biochemical Sciences
|April 27, 2024
PubMed
Summary

Scientists discovered that bacterial and archaeal Toll/interleukin-1 receptor (TIR) domain proteins can remove NAD+-modified RNA (NAD-RNA) caps. This decapping action produces a novel cyclic ADP ribose RNA variant, expanding the known NAD-RNA landscape.

Keywords:
NAD-RNARNA capRNA modificationRNA turnoverdecapping

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