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Establishment of a Clinic-based Biorepository
Published on: May 29, 2017
The Minhang Pediatric Biobank cohort study: protocol overview and baseline characteristics
Xiaosa Wen1, Xinyue Zhang2, Yun Qiu3
1Minhang District Center for Disease Control and Prevention, Shanghai, China.
Insights
The Minhang Pediatric Biobank (MPB) cohort study established a valuable platform for investigating environmental and lifestyle factors in childhood diseases. This research identified common childhood illnesses in Shanghai school children.
Area of Science:
- Pediatric Biobanking
- Environmental Health Research
- Childhood Disease Epidemiology
Background:
- Limited biobanking efforts exist for studying environmental and lifestyle disease risks in school-aged children.
- The Minhang Pediatric Biobank (MPB) cohort study was initiated to address this gap in Shanghai.
Purpose of the Study:
- To establish a biobank for school-aged children in Shanghai.
- To identify environmental and lifestyle risk factors associated with childhood health and diseases.
Main Methods:
- Population-based cohort study initiated in 2014 across Minhang district, Shanghai.
- Enrollment of first-grade elementary students during routine physical exams.
- Collection of self-administered questionnaires from primary caregivers, health information system data, and biological samples (urine, saliva).
Main Results:
- Recruited 8412 children and parents, with 4339 boys and 4073 girls.
- Collected 7128 urine and 2767 saliva samples during the baseline survey.
- Identified dental caries, bronchitis, pneumonia, asthma, and overweight/obesity as the five most prevalent childhood diseases.
Conclusions:
- Successfully established the Minhang Pediatric Biobank (MPB) cohort.
- The biobank serves as a crucial platform for future research on childhood diseases.
- Facilitates investigation into genetic, environmental, and lifestyle risk factors affecting children's health.
Background:
Little has been done to establish biobanks for studying the environment and lifestyle risk factors for diseases among the school-age children. The Minhang Pediatric Biobank (MPB) cohort study aims to identify factors associated with health and diseases of school-aged children living in the urban or suburban area of Shanghai.
Methods:
This population-based cohort study was started in all sub-districts/towns of Minhang district of Shanghai in 2014. First-grade students in elementary school were enrolled during the time of their routine physical examinations, with self-administered questionnaires completed by their primary caregivers. Additional information was extracted from multiple health information systems. Urine and saliva samples were collected during the baseline survey and follow-up visits.
Results:
At the end of 2014 academic year, a total number of 8412 children and their parents were recruited, including 4339 boys and 4073 girls. All the participants completed the baseline survey and physical examination, and 7128 urine and 2767 saliva samples were collected. The five most prevalent childhood diseases in this population were dental caries, bronchitis, pneumonia, asthma and overweight/obese.
Conclusions:
The MPB cohort has been successfully established, serving as a useful platform for future research relating to the genetic, environmental and lifestyle risk factors for childhood diseases.
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