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Navigating biologic therapies in elderly asthma.

HyeIn Ji1, Laren D Tan2, George W Hafzalla1

  • 1Department of Medicine, Loma Linda University Health, Loma Linda, CA, USA.

Respiratory Medicine
|April 28, 2024
PubMed
Summary
This summary is machine-generated.

Biologic therapies show promise for severe asthma in older adults, but research is lacking. Future studies must include elderly patients to improve treatment and outcomes for this growing population.

Keywords:
AsthmaAsthmaticsBiologicsEfficacyElderlySafety

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Area of Science:

  • Gerontology
  • Pulmonology
  • Pharmacology

Background:

  • Asthma prevalence is increasing in the elderly, posing diagnostic and management challenges.
  • Biologic therapies target severe asthma pathways effectively in elderly individuals.
  • A significant research gap exists regarding biologic therapy application in elderly asthma patients.

Purpose of the Study:

  • To review the current landscape of biologic therapies for elderly asthma patients.
  • To highlight the need for dedicated clinical trials and research including elderly participants.
  • To discuss challenges and considerations for using biologic therapies in this demographic.

Main Methods:

  • Review of existing literature on biologic therapies for asthma in the elderly.
  • Analysis of clinical trial designs and exclusion criteria impacting elderly inclusion.
  • Examination of observational studies on biologic therapy efficacy and safety in older adults.

Main Results:

  • No randomized controlled trials (RCTs) are specifically designed for the elderly across all asthma biologics.
  • Most RCTs exclude elderly individuals or those with common comorbidities.
  • Observational studies suggest comparable benefits of biologics in elderly versus non-elderly adults.

Conclusions:

  • Elderly asthma patients are underrepresented in research, hindering evidence-based treatment.
  • There is a critical need for intentional inclusion of elderly participants in future clinical trials.
  • Tailored, evidence-based approaches are essential to optimize biologic therapy for elderly asthma patients.