Related Experiment Video

Updated: Jun 27, 2025

Author Spotlight: RNA FISH for Locating lncRNA-SNHG6 in Osteosarcoma Cells
05:27

Author Spotlight: RNA FISH for Locating lncRNA-SNHG6 in Osteosarcoma Cells

Published on: June 16, 2023

1.4K

Alteration in the Expression of Circular Rnas and its association with the Development and Progression of

Felipe Alves De Lima1, Fernando Liberalino Fernandes1, Daria Raquel Queiroz De Almeida1

  • 1Department of Biomedical Sciences, Rio Grande do Norte State University, Mossoró, Brazil.

Asian Pacific Journal of Cancer Prevention : APJCP
|April 29, 2024
PubMed
Abstract

Insights

Circular RNAs (circRNAs) are significantly altered in osteosarcoma, often increasing and promoting cancer hallmarks like metastasis. These circRNAs may serve as novel biomarkers and therapeutic targets for this aggressive bone cancer.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Osteosarcoma is a prevalent and aggressive bone cancer with poor prognosis.
  • Circular RNAs (circRNAs) are emerging regulators of gene expression, acting as microRNA sponges.
  • Recent evidence links circRNAs to osteosarcoma development and progression.

Purpose of the Study:

  • To investigate alterations in circRNA expression during osteosarcoma development and progression.
  • To identify the role of circRNAs in osteosarcoma hallmarks and clinical outcomes.

Main Methods:

  • An integrative literature review was performed from September to November 2021.
  • Databases searched included PubMed/MEDLINE, SCOPUS, Web of Science, OVID, and EMBASE.
  • 129 full articles were analyzed for circRNA expression, mechanisms, and clinical correlations.

Main Results:

  • 94 distinct circRNAs were identified, with a predominant increase in expression.
  • circRNAs primarily function as microRNA sponges, influencing hallmarks like proliferation, invasion, and apoptosis resistance.
  • Altered circRNA expression correlated with worse prognosis, including shorter survival and increased metastasis.

Conclusions:

  • circRNA molecules play a significant role in osteosarcoma carcinogenesis.
  • circRNAs show potential as novel prognostic and diagnostic biomarkers for osteosarcoma.
  • circRNAs may represent alternative therapeutic targets for osteosarcoma treatment.
Keywords:
Circular RNAOncogenesisosteosarcoma

More Related Videos

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma08:07

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma

Published on: April 12, 2019

7.2K
A Syngeneic Orthotopic Osteosarcoma Sprague Dawley Rat Model with Amputation to Control Metastasis Rate07:31

A Syngeneic Orthotopic Osteosarcoma Sprague Dawley Rat Model with Amputation to Control Metastasis Rate

Published on: May 3, 2021

3.6K

Related Concept Videos

mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
3.8K
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
3.0K
RNA Splicing01:32

RNA Splicing

Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...
56.3K
Experimental RNAi02:15

Experimental RNAi

RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing its transcription or activating the RNA degradation process. The mechanism was discovered by Andrew Fire and Craig Mello in 1998 in plants. Today, it is observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals. This precise cellular mechanism of gene silencing has been developed into a technique that provides an efficient way to identify and determine the...
6.1K
The Nucleolus02:55

The Nucleolus

The nucleolus is the most prominent substructure of the nucleus. When it was first discovered, it was considered to be an isolated organelle that forms fibrils and granules. In 1931, the relationship between the nucleolus and chromosomes was first described by Heitz. He observed that the appearance and size of nucleolus varies depending on the stage of the cell cycle. He also noticed constricted regions on different chromosomes clustered together at definite cell cycle stages. These regions,...
8.8K
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.5K