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Staphylococcus lugdunensis Endocarditis Presenting with Brain Abscesses and Temporal Vision Deficits

Matthew S Linz1, Diana Finkel2, Eli S Goshorn2

  • 1Rutgers New Jersey Medical School, Newark, NJ 07103, USA.

Case Reports in Infectious Diseases
|April 29, 2024
PubMed

Insights

Staphylococcus lugdunensis, a skin bacterium, can cause rare but aggressive infectious endocarditis. Molecular testing identified S. lugdunensis in a culture-negative case with severe complications, highlighting its potential virulence.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Cardiology

Background:

  • Staphylococcus lugdunensis is a coagulase-negative staphylococcal bacterium (CoNS) commonly found on human skin.
  • Infectious endocarditis (IE) caused by S. lugdunensis is infrequent but often presents with a severe clinical trajectory.

Observation:

  • A case of culture-negative IE presented with severe neurological and cardiac complications.
  • The patient experienced brain abscesses, vision deficits, and progressive heart failure.

Findings:

  • S. lugdunensis was identified as the causative agent of IE.
  • Molecular testing of valvular tissue was crucial for diagnosis in this culture-negative case.

Implications:

  • Highlights the potential for S. lugdunensis to cause severe IE, even when initial cultures are negative.
  • Emphasizes the importance of advanced diagnostic methods like molecular testing in complex IE cases.
  • Suggests a need for increased awareness of S. lugdunensis as a pathogen in aggressive endocarditis.

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