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Updated: Jun 27, 2025

Rapid Homogeneous Detection of Biological Assays Using Magnetic Modulation Biosensing System
Published on: June 13, 2010
An optically pumped magnetic gradiometer for the detection of human biomagnetism
Harry Cook1, Yulia Bezsudnova1, Lari M Koponen2
1School of Physics and Astronomy, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom.
Abstract:
We realise an intrinsic optically pumped magnetic gradiometer based on non-linear magneto-optical rotation. We show that our sensor can reach a gradiometric sensitivity of 18 fT and can reject common mode homogeneous magnetic field noise with up to 30 dB attenuation. We demonstrate that our magnetic field gradiometer is sufficiently sensitive and resilient to be employed in biomagnetic applications. In particular, we are able to record the auditory evoked response of the human brain, and to perform real-time magnetocardiography in the presence of external magnetic field disturbances. Our gradiometer provides complementary capabilities in human biomagnetic sensing to optically pumped magnetometers, and opens new avenues in the detection of human biomagnetism.

