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Updated: Jun 27, 2025

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Melanocyte-Keratinocyte Transplantation in Post-Burn Leukoderma Scars: Preliminary Experience Using a Modified

N A Louri1, N Dey1,2, R F De Sousa1

  • 1Plastic Surgery and Burn Unit, Bahrain Defence Force Royal Medical Services, Military Hospital, Bahrain.

Annals of Burns and Fire Disasters
|April 29, 2024
PubMed
Summary

Melanocyte-keratinocyte transplantation (MKTP) effectively repigments post-burn leukoderma patches. This single-stage surgical treatment showed high patient satisfaction and significant repigmentation in a small study.

Keywords:
melanocyte-keratinocyte transplantationpost-burn leukodermarepigmentation

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Area of Science:

  • Dermatology
  • Regenerative Medicine
  • Plastic Surgery

Background:

  • Post-burn leukoderma, prevalent in African and Asian populations, stems from deep dermal burns.
  • The condition causes significant social stigma, impacting survivor rehabilitation and societal reintegration.
  • Current treatment options for post-burn leukoderma are limited, with repigmentation challenges.

Purpose of the Study:

  • To evaluate the efficacy of single-stage Melanocyte-Keratinocyte Transplantation (MKTP) for treating post-burn leukoderma.
  • To assess the repigmentation success and patient satisfaction following MKTP in post-burn leukoderma patients.

Main Methods:

  • Six patients with ten post-burn leukoderma patches underwent single-stage MKTP without adjuvant therapy.
  • The average treated area was 16.25±9 cm².
  • Postoperative follow-up ranged from 12 to 24 months.

Main Results:

  • Significant repigmentation (92.16±11.05%) was observed within one year post-MKTP.
  • All six patients reported satisfaction with the treatment outcomes.
  • The treatment was effective for repigmenting post-burn leukoderma patches.

Conclusions:

  • Single-stage Melanocyte-Keratinocyte Transplantation (MKTP) is an effective surgical option for treating post-burn leukoderma.
  • MKTP offers a promising solution for repigmentation without the need for adjuvant therapies.
  • Further research with larger cohorts and extended follow-up is recommended.