Related Experiment Video
Updated: Jun 27, 2025

Author Spotlight: Integrating Alveolar-Capillary Reserve Measurements in Exercise Adaptation and Therapeutic Strategies
Published on: February 2, 2024
An example of ventilatory limitation during cardiopulmonary exercise testing in a patient with COPD
Claude S Farah1,2,3, Leigh M Seccombe1,2, Greg G King1,4,5
1Faculty of Medicine and Health The University of Sydney Sydney New South Wales Australia.
Abstract:
A 64-year-old obese gentleman attended for further evaluation of ongoing dyspnoea in the context of a previous diagnosis of moderate COPD treated with dual long-acting bronchodilators. A cardiopulmonary exercise test (CPET) was performed, which demonstrated reduced peak work and oxygen consumption with evidence of dynamic hyperinflation, abnormal gas exchange and ventilatory limitation despite cardiac reserve. The CPET clarified the physiological process underpinning the patient's dyspnoea and limiting the patient's activities. This, in turn, helped the clinician tailor the patient's management plan.
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