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Successful Treatment of Refractory Trichodynia With Onabotulinumtoxin-A

Faris A Alhomida1, Sarah Alkhezzi1, Rasha Alshammari1

  • 1Dermatology, King Fahad Medical City, Riyadh, SAU.

Cureus
|April 29, 2024
PubMed

Keywords:
botoxbotulinum toxinhair lossoff-labelpainprocedurepsychiatric co-morbiditiesscalp dysesthesiatreatmenttrichodynia

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Directly acting muscle relaxants like dantrolene and botulinum toxin (BoNT) have distinct mechanisms and applications. Dantrolene, a hydantoin derivative, acts on the ryanodine receptor (RYR1) in skeletal muscle cells. RYR1 are calcium channels present at the sarcoplasmic reticulum membrane. In response to excitation, they release calcium ions from the sarcoplasmic reticulum to the cytosol. Calcium promotes actin-myosin-mediated contraction of muscles.
The binding of dantrolene to the RYR1...