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Related Concept Videos

Enzymes02:34

Enzymes

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Inside living organisms, enzymes act as catalysts for many biochemical reactions involved in cellular metabolism. The role of enzymes is to reduce the activation energies of biochemical reactions by forming complexes with its substrates. The lowering of activation energies favor an increase in the rates of biochemical reactions.
Enzyme deficiencies can often translate into life-threatening diseases. For example, a genetic abnormality resulting in the deficiency of the enzyme G6PD...
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For many years, scientists thought that enzyme-substrate binding took place in a simple "lock-and-key" fashion. This model stated that the enzyme and substrate fit together perfectly in one instantaneous step. However, current research supports a more refined view scientists call induced fit. The induced-fit model expands upon the lock-and-key model by describing a more dynamic interaction between enzyme and substrate. As the enzyme and substrate come together, their interaction causes...
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Rapid Mix Preparation of Bioinspired Nanoscale Hydroxyapatite for Biomedical Applications
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Hydroxyapatite: An Eco-Friendly Material for Enzyme Immobilization.

Leonardo Gelati1,2, Marco Rabuffetti1, Maurizio Benaglia1

  • 1Dipartimento di Chimica, Università degli studi di Milano, via C. Golgi 19, 20133, Milano, Italy.

Chempluschem
|April 29, 2024
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Summary

Hydroxyapatite (HAP) offers a sustainable and cost-effective solution for enzyme immobilization. This eco-friendly biomaterial enhances biocatalyst performance and recyclability for greener chemical synthesis.

Keywords:
enzyme catalysishydroxyapatiteimmobilizationsupported catalystssustainable Chemistry

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Area of Science:

  • Biocatalysis and Green Chemistry
  • Biomaterials Science
  • Enzyme Engineering

Background:

  • Biocatalysis utilizes enzymes for eco-friendly chemical synthesis under mild conditions, offering high selectivity.
  • Enzyme immobilization on solid supports enhances reaction control and catalyst recyclability, crucial for economic viability.
  • Sustainable enzyme immobilization requires eco-friendly and renewable support materials.

Purpose of the Study:

  • To review the application of hydroxyapatite (HAP) as a support for enzyme immobilization.
  • To highlight the advantages of HAP, including its biocompatibility, low cost, and high surface area.
  • To discuss various enzyme classes, immobilization strategies, and HAP-based supports for biocatalysis.

Main Methods:

  • Literature review focusing on enzyme immobilization techniques using hydroxyapatite.
  • Analysis of HAP properties relevant to protein affinity and stability.
  • Evaluation of different enzyme classes and immobilization strategies on HAP supports.

Main Results:

  • Hydroxyapatite (HAP) demonstrates excellent biocompatibility, non-toxicity, and high protein affinity.
  • HAP supports facilitate enzyme immobilization for various classes, maintaining high catalytic activity and selectivity.
  • Immobilization on HAP enables efficient biocatalyst recycling, improving process economics.

Conclusions:

  • Hydroxyapatite is a promising, sustainable biomaterial for enzyme immobilization in green chemistry.
  • HAP-based biocatalysts offer enhanced stability, reusability, and cost-effectiveness.
  • Further exploration of HAP supports can advance the large-scale application of biocatalysis.