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Updated: Jun 27, 2025

Preparation of N-2-alkoxyvinylsulfonamides from N-tosyl-1,2,3-triazoles and Subsequent Conversion to Substituted Phthalans and Phenethylamines
Published on: January 3, 2018
Copper-Catalyzed Sulfur Alkylation of Sulfenamides with N-Sulfonylhydrazones
Yidan Han1, Yin Yuan2, Shutao Qi2
1College of Chemistry and Bioengineering, Guilin University of Technology, Guilin, Guangxi 541006, People's Republic of China.
Abstract:
Sulfilimines are valuable compounds in both organic synthesis and pharmaceuticals. In this study, we present a copper-catalyzed sulfur alkylation of sulfenamides with N-sulfonylhydrazones. In contrast to prior findings, hydrazones derived from aldehydes act as donor-type carbene precursors, effectively engaging in coupling with sulfenamides via a copper catalyst, demonstrating exclusive S selectivity. The utility of the protocol was highlighted in the rapid access to a wide range of sulfoximine derivatives.
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