A stochastic approach in the evaluation of plasma curves with enterohepatic recycling

The precision of the existing methods for evaluation of compartmental models may not be warranted if the plasma curve is irregular due to enterohepatic recycling of the substance during its elimination. In this work a new approach is proposed which involves the assessments of rate-constants using combined cross-sectional and time-series data. As (C0-Cpl) means the concentration of the drug in the environmental compartment, the (Formula: see text) equation is valid for the change in the plasma concentration level. Calculating the correlation coefficients (r) for the Cpl and (C0-Cpl) data-pairs from the cross-sectional data, in this case the time-derivatives of these correlation coefficients are equal to the rate constants.