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Localized Surface Plasmon Resonance Sensing and its Interplay with Fluidics.
Nikhil Bhalla1,2, Amy Q Shen3
1Nanotechnology and Integrated Bioengineering Centre (NIBEC), School of Engineering, Ulster University, Belfast BT15 1AP, United Kingdom.
Langmuir : the ACS Journal of Surfaces and Colloids
|April 29, 2024
Summary
This article explores how fluidics enhances localized surface plasmon resonance (LSPR) sensing for real-time bio/chemical detection. The integration of microfluidics with LSPR technology enables advanced fluid dynamics studies and direct biological fluid analysis.
Area of Science:
- Analytical Chemistry
- Biotechnology
- Materials Science
Background:
- Localized surface plasmon resonance (LSPR) is a powerful optical sensing technique.
- Microfluidics offers precise control over fluid environments.
- Integrating these technologies can overcome limitations in current sensing methods.
Purpose of the Study:
- To discuss the synergy between fluidics and LSPR sensing.
- To highlight applications in bio/chemical sensing within fluidic systems.
- To explore novel interfacial phenomena detection.
Main Methods:
- Overview of LSPR sensing principles.
- Development of an integrated LSPR chip with microfluidic structures.
- Real-time monitoring of biological processes and fluid analysis.
Main Results:
- Demonstrated integration of microfluidics with LSPR for enhanced sensing.
- Successful real-time monitoring of DNA polymerase activity.
- Direct sensing of biological fluids like urine and observation of particle assembly.
Conclusions:
- The combination of fluidics and LSPR sensing significantly expands research capabilities.
- This integrated approach offers unique advantages for studying interfacial phenomena.
- Future opportunities exist at the intersection of fluidics and LSPR sensing.
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