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Evaluation of Melatonin and its Nanostructures Effects on Skin Disorders Focused on Wound Healing
Seyedeh Mohaddeseh Mousavi1, Leila Etemad2, Davood Yari3
1School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
Abstract:
Skin is the largest organ of the human body functioning as a great primitive defensive barrier against different harmful environmental factors. However, it is damaged through varying injuries such as different wounds, burns, and skin cancers that cause disruption in internal organs and essential mechanisms of the body through inflammation, oxidation, coagulation problems, infection, etc. Melatonin is the major hormone of the pineal gland that is also effective in skin disorders due to strong antioxidant and anti-inflammatory features with additional desirable antiapoptotic, anti-cancer, and antibiotic properties. However, melatonin characteristics require improvements due to its limited water solubility, halflife and stability. The application of nanocarrier systems can improve its solubility, permeability, and efficiency, as well as inhibit its degradation and promote photostability. Our main purpose in the current review is to explore the possible role of melatonin and melatonin-containing nanocarriers in skin disorders focused on wounds. Additionally, melatonin's effect in regenerative medicine and its structures as a wound dressing in skin damage has been considered.
Insights
Melatonin shows promise for treating skin disorders, particularly wounds, due to its antioxidant and anti-inflammatory properties. Nanocarrier systems enhance melatonin
Area of Science:
- Dermatology and Regenerative Medicine
- Nanotechnology in Medicine
Background:
- Skin serves as a primary defense barrier but is susceptible to injuries like wounds, burns, and cancers.
- These injuries trigger inflammation, oxidation, and infection, disrupting bodily functions.
- Melatonin, a pineal gland hormone, possesses antioxidant, anti-inflammatory, anti-apoptotic, anti-cancer, and antibiotic properties beneficial for skin disorders.
Purpose of the Study:
- To review the therapeutic potential of melatonin in skin disorders, with a focus on wound healing.
- To explore the use of melatonin-loaded nanocarriers for improved skin delivery and efficacy.
- To consider melatonin's role in regenerative medicine and as a wound dressing component.
Main Methods:
- Literature review of studies on melatonin's effects on skin.
- Analysis of research on nanocarrier systems for melatonin delivery.
- Examination of melatonin's application in wound dressings and regenerative medicine.
Main Results:
- Melatonin exhibits significant antioxidant and anti-inflammatory effects relevant to skin repair.
- Nanocarrier systems can overcome melatonin's limitations (solubility, stability, half-life), enhancing its skin permeability and efficacy.
- Melatonin-based strategies show potential in wound healing and regenerative medicine.
Conclusions:
- Melatonin is a promising agent for managing skin injuries, especially wounds.
- Nanotechnology-based delivery systems are crucial for optimizing melatonin's therapeutic benefits in dermatology.
- Further research into melatonin-loaded nanocarriers could lead to advanced wound healing and regenerative therapies.
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