Nickel-Catalyzed Lactamization Reaction of 2-Arylanilines with CO2
Lu Wang1, Hanxuan Wu1, Yucheng Zhao1
1State Key Laboratory of Elemento-Organic Chemistry and Frontiers Science Center for New Organic Matter, College of Chemistry, Nankai University, Tianjin 300071, People's Republic of China.
Abstract:
Transition-metal-catalyzed lactamization and lactonization of C-H bonds with CO2 assisted by the chelation of amino or hydroxyl groups have been developed but limited to the use of precious metal catalysts such as palladium and rhodium. In this work, we report the nonprecious metal nickel-catalyzed lactamization reaction of 2-arylanilines with CO2 under redox-neutral conditions via C-H bond activation. The reaction displayed excellent functional group tolerance, providing various phenanthridinones with moderate to high yields.
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