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Updated: Jun 27, 2025
Preparation, Purification, and Characterization of Lanthanide Complexes for Use as Contrast Agents for Magnetic Resonance Imaging
Published on: July 21, 2011
Multifunctional Amino Acid Derivative Coordination Compounds: Novel Contrast Agent and Luminescence Materials
Estitxu Echenique-Errandonea1, Sara Rojas2, Ana M Ortuño2
1Department of Applied Chemistry, Faculty of Chemistry, University of Basque Country/Euskal Herriko Unibertsitatea (UPV/EHU), 20018, Donostia, Spain.
Abstract:
In this work a family of multidimensional (2-(1H-tetrazol-5-yl)ethyl) amino acid coordination compounds have been synthesized and thoroughly characterized. For this purpose, glycine, valine, phenylalanine and tyrosine have been selected as starting amino acids and Mn2+, Zn2+ and Cd2+ as metallic nodes. From one side, for Mn2+ based dimer magnetic resonance imaging studies have been conducted, prompted by the number and disposition of the coordinated water molecules and taking into consideration the promising future of manganese-based coordination compounds as bio-compatible substitutes to conventional Gd based contrast agents. From another side, d10 block metal-based complexes allowed exploring photoluminescence properties derived by in situ synthesized ligands. Finally, amino acid preserved structural chirality allowed us to examine chiroptical properties, particularly focusing on circularly polarized luminescence.
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