[Anti-bacterial effect of ofloxacin--in vitro and in vivo results]

Gram (-) bacteria such as E. coli, B. proteus, Klebsiella and Pseudomonas sp were found to be sensitive to Ofloxacin 98.3%, 96.7%, 96.9%, and 89.1% respectively. Among Gram (+) bacteria, 98% of Staph aureus and 95% of Staph epidermidis were susceptible to this drug. The minimum inhibitory concentrations of Ofloxacin for the Shigella strains have been found to be between 0.1-0.05 mcg/ml (76%) and 0.05-0.025 mcg/ml (20%). Thirty three patients with various infection have been treated with ofloxacin; in acute cases the efficacy of the drug was 100%, but reinfections or relapse developed in about half of the patients with chronic and complicated urinary tract infections, 15-20 days after discontinuation of the drug. No serious side effect has been observed.