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Mannose-binding lectin gene sequence data in Kelantan population
Muhamad Aidil Zahidin1, Noor Haslina Mohd Noor2,3, Muhammad Farid Johan1
1Department of Haematology, School of Medical Sciences, Universiti Sains Malaysia (Health Campus), 16150, Kubang Kerian, Kelantan, Malaysia.
Scientific Data
|April 30, 2024
Summary
This study presents the first human mannose-binding lectin (MBL) gene sequencing data from Malaysia. It identifies six MBL haplotypes, establishing a crucial baseline for future disease association research in the region.
Area of Science:
- Immunology
- Genetics
Background:
- The human mannose-binding lectin (MBL) gene is vital for innate immunity.
- MBL deficiency and variants are linked to various diseases, including autoimmune and infectious conditions.
- MBL gene studies are infrequent in Malaysia.
Purpose of the Study:
- To preliminarily describe the human MBL gene sequencing dataset from the Kelantan population in Malaysia.
- To establish a baseline for MBL genetic information within the country.
- To identify MBL allelic variants and haplotypes in the studied population.
Main Methods:
- DNA extraction from blood samples of 30 unrelated individuals.
- Genotyping and sequencing of the human MBL gene.
- Bioinformatic analysis to identify variants and construct an evolutionary tree.
Main Results:
- Generated 886 bp of human MBL sequencing data, deposited in GenBank (accession numbers ON619541-ON619546).
- Identified allelic variants leading to six distinct MBL haplotypes: HYPA, HYPB, LYPB, LXPB, HXPA, and LXPA.
- Constructed an evolutionary tree based on the identified MBL haplotype sequences.
Conclusions:
- This study provides the initial human MBL gene sequencing data from Malaysia.
- The identified MBL haplotypes offer a foundational dataset for future research.
- This baseline data is essential for investigating MBL gene associations with diseases in the Malaysian population.
