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Updated: Jun 27, 2025

Synthesis and Bioconjugation of Thiol-Reactive Reagents for the Creation of Site-Selectively Modified Immunoconjugates
Published on: March 6, 2019
Metal-Free Photoredox Catalyzed Sulfonylation of Phenylhydrazines with Thiols
Ambuj Kumar Kushwaha1, Arsala Kamal1, Pooja Kumari1
1Department of Chemistry, Indian Institute of Technology (BHU), Varanasi - 221 005, U.P., India.
Abstract:
The sulfonylation method stands out as a simple and efficient approach for synthesizing sulfonamides. Despite the advancements in constructing the sulfonamide framework, the potential use of phenyl hydrazine as an amination source remains unexplored. Herein, we report a metal-free, environment-friendly photoredox-catalyzed sulfonylation of phenylhydrazines using thiols, employing MeCN:H2O as a green solvent and eosin Y as a photoredox catalyst. This strategy exhibits a broad substrate scope and good functional group compatibility, including hetero(aryl) as well as aliphatic phenylhydrazines. Finally, this protocol also demonstrated good application for the synthesis of pharmaceutical analogues.
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