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Related Concept Videos

Proteomics01:33

Proteomics

7.3K
A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
7.3K
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
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Related Experiment Video

Updated: Jun 27, 2025

Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification
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Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification

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Proteomics appending a complementary dimension to precision oncotherapy.

Zhaokai Zhou1,2, Ruiqi Zhang1, Aoyang Zhou1

  • 1Department of Interventional Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China.

Computational and Structural Biotechnology Journal
|May 1, 2024
PubMed
Summary

High-throughput proteomics enables precise protein quantification for analyzing molecular signatures. This review explores proteomics technologies and data integration for advancing precision medicine and tumor treatment.

Keywords:
Data integrationMolecular typingPrecision oncotherapyProtein networkProteomicsProteomics analysis technology

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Area of Science:

  • Biochemistry
  • Molecular Biology
  • Proteomics

Background:

  • High-throughput proteomic profiling allows precise quantification of multiple proteins across specimens.
  • Advances in data analysis facilitate the integration and consolidation of proteomics data.
  • Proteomics aids in understanding molecular mechanisms and identifying biomarkers for precision medicine.

Purpose of the Study:

  • To review current proteomics technologies.
  • To discuss progress and methods for proteomics data integration.
  • To explore the integration of proteomics into precision medicine and clinical settings.

Main Methods:

  • Review of high-throughput proteomic profiling technologies.
  • Analysis of data integration methods for proteomics.
  • Discussion of applications in precision medicine and clinical settings.

Main Results:

  • Proteomics technologies offer comprehensive molecular signature analysis.
  • Integrated proteomics data can identify key molecular mechanisms and biomarkers.
  • The potential for merging proteomics in precision medicine is significant.

Conclusions:

  • Proteomics is a powerful tool for molecular analysis in research and clinical settings.
  • Data integration is crucial for leveraging proteomics in precision medicine.
  • Further integration of proteomics will enhance precision treatment of tumors.