Aspirin interruption before neurosurgical interventions: A controversial problem

Alexander Kulikov1, Anton Konovalov2, Pier Paolo Pugnaloni3

  • 1Department of Anesthesiology, Burdenko National Medical Research Center of Neurosurgery, Moscow 125047, Russia.

PubMed

Insights

Chronic aspirin use may not require interruption before neurosurgery, challenging current guidelines. This review examines aspirin

Area of Science:

  • Neurosurgery
  • Cardiology
  • Pharmacology

Background:

  • Aspirin is common for preventing ischemic events.
  • Chronic aspirin use may increase surgical bleeding risk.
  • Neurosurgical guidelines recommend aspirin cessation 7 days prior, lacking strong evidence.

Purpose of the Study:

  • To review evidence challenging the necessity of aspirin interruption before neurosurgery.
  • To discuss aspirin effect monitoring and its clinical implications.
  • To summarize bleeding risk data for aspirin users undergoing neurosurgery.

Main Methods:

  • Narrative review of existing literature.
  • Analysis of clinical data on aspirin and bleeding in neurosurgical patients.
  • Evaluation of aspirin effect monitoring techniques.

Main Results:

  • Evidence suggests aspirin interruption may not be necessary for all neurosurgical patients.
  • Aspirin effect monitoring offers options for managing perioperative risk.
  • Bleeding risk varies across different neurosurgical procedures (brain tumors, cerebrovascular, spinal).

Conclusions:

  • Current guidelines for aspirin interruption before neurosurgery may be overly cautious.
  • Personalized management based on aspirin effect monitoring and procedure type is warranted.
  • Further research is needed to refine recommendations for aspirin use in neurosurgery.

Related Concept Videos

Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors01:20

Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors

Antiplatelet drugs emerge as frontline defenders against the insidious threat of thromboembolic diseases, where abnormal clots obstruct vital blood vessels. These drugs stand as bulwarks, inhibiting platelet aggregation and clot formation, thereby mitigating the risk of life-threatening conditions like myocardial infarction, coronary artery disease, and thrombotic strokes.
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...
522
Depolarizing Blockers: Pharmocokinetics01:19

Depolarizing Blockers: Pharmocokinetics

Depolarizing blockers are administered through intravenous injection. Succinylcholine is the most common choice of depolarizing blockers in emergency clinical practices. Although they have a rapid onset, they readily diffuse away from the motor end plate into the extracellular fluid. They are metabolized by enzymes such as liver butyrylcholinesterase and plasma pseudocholinesterases. This produces a short duration of action, typically 5-10 minutes long, unlike nondepolarizing blockers, which...
323
Epistaxis01:30

Epistaxis

Epistaxis, or nosebleeds, occurs when small, swollen blood vessels in the nasal mucous membrane rupture. Typically, the anterior septum is the primary site of occurrence.
Etiology
Possible causes of this condition include high blood pressure, trauma, low humidity, upper respiratory tract infections, allergies, foreign bodies, nasal inhalation of corticosteroids or illicit drugs, excessive use of decongestant nasal sprays, facial or nasal surgery, anatomic malformation, tumors, or systemic...
151
Nondepolarizing (Competitive) Neuromuscular Blockers: Pharmacological Actions01:27

Nondepolarizing (Competitive) Neuromuscular Blockers: Pharmacological Actions

Nondepolarizing neuromuscular blockers prevent the membrane depolarization of muscle cells and inhibit muscle contraction. These are usually administered with anesthetics to achieve complete muscle relaxation. Upon administration, these drugs first block the small, rapidly contracting muscles of the face and hands, followed by the larger muscles of the trunk and the intercostal muscles. The diaphragm is the last muscle to be affected.
Although all competitive neuromuscular blockers are designed...
416
General Anesthesia: Overview01:24

General Anesthesia: Overview

Anesthesia is a medical procedure that uses drugs for CNS suppression to enable painless surgeries and procedures. The selection of anesthetics is influenced by their pharmacokinetic properties, side effects, and patient characteristics. Various types of anesthesia include general, local, regional, spinal, and inhalational.
General anesthesia induces unconsciousness in the whole body, while the others target specific areas or sensations. It is administered to minimize adverse effects, maintain...
214
Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists01:28

Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists

Neurokinin 1 (NK1) receptors are distributed across the GI tract, vagal afferents, and key CNS regions including the central vomiting center and chemoreceptor trigger zone (CTZ) Chemotherapy agents stimulate enterochromaffin cells in the gastrointestinal (GI) tract to release large amounts of substance P (SP). SP is a neuropeptide released by specific sensory nerves in response to many different stressors, including those in the GI mucosa affected by chemotherapy.  SP binds and activates...
160