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Updated: Jun 24, 2026
28:13
Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
Published on: February 26, 2013
33.4K
Impact of Contact Force on Pulsed Field Ablation Outcomes Using Focal Point Catheter
Arwa Younis1, Pasquale Santangeli1, Kara Garrott2
1Cardiac Electrophysiology Section, Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, OH (A.Y., P.S., C.T., S.Y.W., A.A.H., S.N., H.N., T.T., M.K., J.S., W.I.S., O.M.W.).
Circulation. Arrhythmia and Electrophysiology
|May 1, 2024
Summary
Pulsed field (PF) ablation creates wider atrial lesions than radiofrequency ablation. Contact force (CF) significantly increases PF lesion depth, offering a new approach for arrhythmia treatment.
Area of Science:
- Electrophysiology
- Medical Devices
- Cardiovascular Research
Background:
- Conventional focal radiofrequency catheters can be adapted for pulsed field (PF) or radiofrequency (RF) energy delivery.
- Contact force (CF) feedback offers enhanced flexibility in arrhythmia treatment.
- Limited data exists on the impact of CF on lesion formation during PF ablations.
Purpose of the Study:
- To compare atrial lesion formation between PF and RF energy modalities.
- To investigate the effect of varying contact force (CF) levels on lesion dimensions during PF ablation.
Main Methods:
- An in vivo swine model was used with an investigational dual-energy focal catheter.
- Experiment I: Point-by-point intercaval lines were created using RF and PF energy.
- Experiment II: Discrete ventricular lesions were created using PF with low, medium, and high CF levels.
Main Results:
- Both RF and PF energy created complete, transmural atrial lesions.
- PF ablation resulted in significantly wider atrial lesion lines compared to RF (P<0.01).
- Higher CF levels during PF ablation correlated with increased lesion depth (r=0.82, P<0.001) and volume (r=0.55, P<0.001).
Conclusions:
- A novel PF ablation waveform using a focal, CF-sensing catheter created wider transmural atrial lesions than RF.
- Lesion depth demonstrated a significant positive correlation with CF during PF ablation.
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