Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

5.7K
Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
5.7K
Genomics02:02

Genomics

36.3K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
36.3K
Multi-species Conserved Sequences02:51

Multi-species Conserved Sequences

3.9K
Next-generation sequencing technologies have created large genomic databases of a variety of animals and plants. Ever since the human genome project was completed, scientists studied the genome of primates, mammals, and other phylogenetically distant living beings. Such large-scale  studies have provided new insights into the evolutionary relationship between organisms.
Although the genome of each species varies greatly from each other, a few sequences are highly conserved. Such conserved...
3.9K
Next-generation Sequencing03:00

Next-generation Sequencing

88.7K
The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features....
88.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Genomic reconstruction of the Pakistani Roma reveals dual South Asian ancestry, medieval bottlenecks, and the early dispersal routes of the Romani people.

Human genomics·2026
Same author

Genetic and linguistic landscapes of Gansu-Qinghai populations.

Fundamental research·2026
Same author

Corrigendum to "Multidisciplinary exploration of ancient atherosclerosis: Paleo-genomic and paleo-nutritional analysis of a 13th century artificial mummy in China" [J. Genet. Genom. (2026) 53, 906-918].

Journal of genetics and genomics = Yi chuan xue bao·2026
Same author

Reconstructing the west-east genetic division in Indonesia using ancient genomes.

iScience·2026
Same author

Multiple Genetic Shifts at the Crossroads of the Eastern Steppe and Loess Plateau Over 4,000 Years.

Nature communications·2026
Same author

Characterization of real-time narrow-band imaging of diminutive colorectal polyp histology: A Chinese national nonaffiliated multicenter investigation.

Chinese medical journal·2026

Related Experiment Video

Updated: Jun 27, 2025

Primer Extension Capture: Targeted Sequence Retrieval from Heavily Degraded DNA Sources
15:28

Primer Extension Capture: Targeted Sequence Retrieval from Heavily Degraded DNA Sources

Published on: September 3, 2009

20.2K

Protocol for a comprehensive pipeline to study ancient human genomes.

Kongyang Zhu1, Haifeng He1, Le Tao1

  • 1State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen 361102, China.

STAR Protocols
|May 1, 2024
PubMed
Summary

This study details a protocol for ancient genomics research, enabling the study of human evolution and migration history through DNA analysis from ancient remains. It covers sample preparation, sequencing, and genetic analysis for uncovering past population diversity.

Keywords:
GeneticsGenomicsSequence analysisSequencing

More Related Videos

Optimized Bone Sampling Protocols for the Retrieval of Ancient DNA from Archaeological Remains
06:18

Optimized Bone Sampling Protocols for the Retrieval of Ancient DNA from Archaeological Remains

Published on: November 30, 2021

3.8K
Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease
09:34

Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease

Published on: April 4, 2018

33.7K

Related Experiment Videos

Last Updated: Jun 27, 2025

Primer Extension Capture: Targeted Sequence Retrieval from Heavily Degraded DNA Sources
15:28

Primer Extension Capture: Targeted Sequence Retrieval from Heavily Degraded DNA Sources

Published on: September 3, 2009

20.2K
Optimized Bone Sampling Protocols for the Retrieval of Ancient DNA from Archaeological Remains
06:18

Optimized Bone Sampling Protocols for the Retrieval of Ancient DNA from Archaeological Remains

Published on: November 30, 2021

3.8K
Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease
09:34

Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease

Published on: April 4, 2018

33.7K

Area of Science:

  • Paleogenomics
  • Human Evolution Studies
  • Population Genetics

Background:

  • Ancient genomics has significantly advanced the understanding of human evolutionary and migration patterns.
  • The study of ancient DNA (aDNA) requires specialized protocols for reliable results.

Purpose of the Study:

  • To present a comprehensive protocol for preparing and analyzing ancient DNA samples.
  • To facilitate research into the genetic history and diversity of ancient populations.

Main Methods:

  • DNA extraction from human remains.
  • DNA library construction and hybridization capture.
  • DNA quantification, sequencing, read mapping, and population genetics analysis.

Main Results:

  • The protocol covers all essential steps from sample preparation to data analysis.
  • It addresses critical challenges in aDNA extraction and authentication.

Conclusions:

  • This protocol provides a standardized method for ancient genomics research.
  • It supports the investigation of human evolutionary history and ancient population dynamics.