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Updated: Jun 27, 2025

Separation of Aldehydes and Reactive Ketones from Mixtures Using a Bisulfite Extraction Protocol
Published on: April 2, 2018
SuFEx-Enabled Direct Deoxy-Diversification of Alcohols
Amaechi Shedrack Odoh1, Courtney Keeler1, Byoungmoo Kim1
1Department of Chemistry, Clemson University, Clemson, South Carolina 29634, United States.
Abstract:
We introduce a new use of sulfonyl fluoride as a bifunctional reagent that facilitates the one-step deoxy-diversification of complex alcohol libraries. Our reaction design features a Sulfur(VI) Fluoride Exchange (SuFEx) mediated activation of alcohols and fluoride-induced activation of silicon-bound nucleophiles. This method enables the direct conversion of alcoholic C-O bonds in complex molecules into diverse analogues via C-C, C-N, C-Cl, and C-Br bond formation while suppressing any elimination side-products.
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