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Published on: August 12, 2019
Enantioselective Deoxygenative Amino-Cyanation of Carboxylic Acids via Ti-Multicatalysis
Giovani Gutierrez1, Jason A Wilt1, Samirah Muhammad1
1Department of Chemistry, Clemson University, Clemson, South Carolina 29634, United States.
Abstract:
Carboxylic acids are valued synthetic building blocks that offer shelf life stability, structural diversity, and wide commercial availability. Despite the remarkable synthetic utility of carboxylic acids, a direct enantioselective deoxygenative functionalization of carboxylic acids remains rare. We present enantioselective deoxygenative amino-cyanation of carboxylic acids using a novel TiIV-multicatalytic system that catalytically modified each C-O bond of carboxylic acid to C-C, C-N, and C-H bonds, generating enantio-enriched chiral α-amino nitriles (up to 98:2 er).
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