Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Regulation of Nuclear Protein Sorting01:45

Regulation of Nuclear Protein Sorting

2.4K
Nuclear protein sorting regulates nucleus composition and gene expression, crucial for determining the fate of a eukaryotic cell. Hence, the entry and exit of molecules across the nuclear envelope is a tightly controlled process. Nuclear protein sorting can be inhibited by one of the following ways: 1) masking cargo signal sequences, 2) modifying the nuclear receptor's affinity for cargo, 3) controlling the nuclear pore size, 4) retaining the cargo during its transit to the cytosol or the...
2.4K
Cells of the Innate Immune Response01:28

Cells of the Innate Immune Response

1.6K
The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
1.6K
Signal Transduction: Overview01:26

Signal Transduction: Overview

8.5K
Cells respond to many types of information, often through receptor proteins positioned on the membrane. They respond to chemical signals, such as hormones, neurotransmitters, and other signaling molecules, initiating a series of molecular reactions to produce an appropriate response. This is called signal transduction. Cells also coordinate different responses elicited by the same signaling molecule via mediators, allowing molecular cross-talk.
Typically, signal transduction involves three...
8.5K
Assembly of Signaling Complexes01:30

Assembly of Signaling Complexes

5.7K
Multiprotein signaling complexes are formed in a dynamic process involving protein-protein interactions at the cytoplasmic domain of transmembrane receptors or enzymatic and non-enzymatic proteins associated with the receptor. These complexes ensure the activation and propagation of intracellular signals that regulate cell functions.
Interaction domains in cell signaling
Interaction domains recognize exposed features of their binding partners containing post-translationally modified sequences,...
5.7K
Protein Networks02:26

Protein Networks

3.9K
An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
3.9K
Mechanism of Filopodia Formation01:39

Mechanism of Filopodia Formation

2.3K
Filopodia are thin, actin-rich cellular protrusions that play an important role in many fundamental cellular functions. They vary in their occurrence, length, and positioning in different cell types, suggesting their diverse roles.
Their main function is to guide migrating cells during normal tissue morphogenesis or cancer metastasis by recognizing and making initial contacts with the extracellular matrix. However, they can also act as stationary cell anchors or help to establish communication...
2.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Strain-Induced Giant Topological Rashba Splitting.

ACS nano·2026
Same author

Extracellularly Activated Logic-Gated DNA Nanodevice for Molecular Transport via Reprogrammed Transferrin Receptor Trafficking.

Small (Weinheim an der Bergstrasse, Germany)·2025
Same author

Functional Connectivity Changes in Primary Motor Cortex Subregions of Patients With Obstructive Sleep Apnea.

Brain and behavior·2025
Same author

Construction of the Lactone-Bridged Scaffold of Alstoscholactine through an Acid-Catalyzed Prins Cyclization/Lactonization Cascade.

Organic letters·2025
Same author

Structuring 3D-printed polypropylene composites with vertically aligned mesophase pitch-based carbon fibers for enhanced through-plane thermal conductivity and mechanical properties.

Materials horizons·2025
Same author

Uniformity, Linearity, and Symmetry Enhancement in TiO<sub></sub>/MoS<sub>2-</sub>O<sub></sub> Based Analog RRAM via S-Vacancy Confined Nanofilament.

Nano letters·2024
Same journal

A Domino-Synthesized Dicoordinate Copper(I) Bis-imidazopyridine Complex Triggering Cuproptosis/Ferroptosis for Enhanced Cancer Immunotherapy.

Angewandte Chemie (International ed. in English)·2026
Same journal

Mirror-Symmetric Organic Two-Dimensional Crystals for Alternative Photon Transport Pathways.

Angewandte Chemie (International ed. in English)·2026
Same journal

Cobalt-Catalyzed Migratory E-Selective Asymmetric Aza-Nozaki-Hiyama-Kishi Coupling.

Angewandte Chemie (International ed. in English)·2026
Same journal

Facile Synthesis of α,ω-Dihydroxy Telechelic Macromonomers From Ethylene and α-Olefins for Recyclable Alternating Block Copolymers.

Angewandte Chemie (International ed. in English)·2026
Same journal

Multi-Atom Sub-Nanometer Assemblies on Interpenetrating Multi-Chambered N/C Nanospheres.

Angewandte Chemie (International ed. in English)·2026
Same journal

A Synergistic C<sub>2+</sub> Alcohols/Olefins-Intermediated Pathway Boosts CO<sub>2</sub> Hydrogenation to Aromatics.

Angewandte Chemie (International ed. in English)·2026
See all related articles

Related Experiment Video

Updated: Jun 27, 2025

Ligand Nano-cluster Arrays in a Supported Lipid Bilayer
10:34

Ligand Nano-cluster Arrays in a Supported Lipid Bilayer

Published on: April 23, 2017

6.9K

NETosis-Inspired Cell Surface-Constrained Framework Nucleic Acids Traps (FNATs) for Cascaded Extracellular

Hangsheng Gong1, Yihan Zhang1, Yuan Xue1

  • 1School of Life Sciences, Anhui Medical University, Hefei, Anhui, 230032, China.

Angewandte Chemie (International Ed. in English)
|May 1, 2024
PubMed
Summary
This summary is machine-generated.

Researchers developed framework nucleic acid traps (FNATs) inspired by neutrophil extracellular traps (NETs). These DNA devices recognize extracellular signals like ATP, inhibit cell migration, and induce cell destruction, offering new tools for molecular medicine.

Keywords:
Adenosine Triphosphate (ATP)Cell Behavior RegulationDNA NanotechnologyFramework Nucleic Acids (FNA)Neutrophil Extracellular Traps (NETs)

More Related Videos

Author Spotlight: Advancements in DNA Nanosensors &#8211; Addressing Sensitivity and Selectivity Challenges in Molecular Detection
07:16

Author Spotlight: Advancements in DNA Nanosensors – Addressing Sensitivity and Selectivity Challenges in Molecular Detection

Published on: February 9, 2024

965
Folding and Characterization of a Bio-responsive Robot from DNA Origami
07:59

Folding and Characterization of a Bio-responsive Robot from DNA Origami

Published on: December 3, 2015

14.6K

Related Experiment Videos

Last Updated: Jun 27, 2025

Ligand Nano-cluster Arrays in a Supported Lipid Bilayer
10:34

Ligand Nano-cluster Arrays in a Supported Lipid Bilayer

Published on: April 23, 2017

6.9K
Author Spotlight: Advancements in DNA Nanosensors &#8211; Addressing Sensitivity and Selectivity Challenges in Molecular Detection
07:16

Author Spotlight: Advancements in DNA Nanosensors – Addressing Sensitivity and Selectivity Challenges in Molecular Detection

Published on: February 9, 2024

965
Folding and Characterization of a Bio-responsive Robot from DNA Origami
07:59

Folding and Characterization of a Bio-responsive Robot from DNA Origami

Published on: December 3, 2015

14.6K

Area of Science:

  • Biotechnology
  • Molecular Biology
  • Nanotechnology

Background:

  • Neutrophils release neutrophil extracellular traps (NETs) to capture pathogens.
  • NETosis is a key immune response involving DNA release.
  • Existing methods lack precise control over cellular behavior and molecular recognition.

Purpose of the Study:

  • To develop programmable, cell surface-constrained DNA nanostructures (FNATs).
  • To enable dynamic recognition of extracellular signaling molecules.
  • To modulate cellular behavior, including migration and self-destruction.

Main Methods:

  • Design and synthesis of framework nucleic acid traps (FNATs).
  • Programming FNATs for adenosine triphosphate (ATP) recognition.
  • Integration of photosensitizer chlorin e6 (Ce6) for photodynamic therapy.
  • In situ self-assembly of FNAs on target cell surfaces.

Main Results:

  • FNATs demonstrated programmable recognition of extracellular ATP.
  • In situ FNA assembly on cell surfaces inhibited target cell migration.
  • Activation of Ce6 induced targeted cell self-destruction.
  • The platform allows visualization of extracellular activities and manipulation of cellular behavior.

Conclusions:

  • FNATs represent a novel DNA-based platform for dynamic molecular recognition and cellular behavior modulation.
  • This technology offers potential applications in diagnostics and therapeutics.
  • Programmable DNA nanodevices provide new tools for manipulating cellular functions in situ.