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Updated: Jun 27, 2025

In Vitro Assay of Plasmodium-Infected Red Blood Cell Killing by Cytotoxic Lymphocytes
Published on: August 17, 2022
[Malaria vaccines: a new tool for elimination?]
Blaise Genton1, Valérie D'Acremont1
1Policlinique de médecine tropicale, voyages et vaccinations, Centre universitaire de médecine générale et santé publique, Unisanté, 1011 Lausanne.
Abstract:
A malaria vaccine represents an essential complementary tool to curb the stagnation, or even increase, in malaria cases observed over the last decade due to the emergence of resistance to insecticides impregnated on mosquito nets, wars and internal conflicts, as well as global warming. In October 2021, WHO recommended the use of the RTS,S/ASO1 vaccine for children aged 5-17 months in areas of moderate to high transmission. In October 2023, a second vaccine received WHO approval for deployment in the same population, following demonstration of around 70 % efficacy in protecting young children against malaria for one year. Given their partial efficacy, however, these vaccines are not generally recommended for travelers to endemic countries.
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