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Resistance Exercise Training Mitigates Cardiac Remodeling Induced by a High-Fat Diet in Rodents: A Systematic Review
Alexandre Martins Oliveira Portes1,2, Sebastião Felipe Ferreira Costa1, Luciano Bernardes Leite1
1Universidade Federal de Viçosa, Viçosa, MG - Brasil.
Arquivos Brasileiros De Cardiologia
|May 2, 2024
Summary
Resistance exercise training (RT) partially counteracts adverse cardiac remodeling in rodents fed a high-fat diet (HFD). RT improves cardiac function and reduces oxidative stress and inflammation, offering potential benefits for cardiovascular health.
Area of Science:
- Cardiovascular Physiology
- Exercise Science
- Metabolic Disease Research
Background:
- Obesity, driven by high-fat diets (HFD), significantly increases cardiovascular disease risk.
- HFD feeding in animal models impairs cardiac structure, function, and promotes cellular damage (oxidative stress, apoptosis).
- Resistance exercise training (RT) is recognized for its role in managing cardiometabolic diseases due to increased energy expenditure and lipolysis.
Conclusions:
- RT demonstrates a partial counteraction of HFD-induced adverse cardiac remodeling.
- Benefits include increased structural remodeling marker activity, elevated mitochondrial biogenesis, and reduced oxidative and inflammatory stress.
- RT also improved hemodynamic, anthropometric, and metabolic parameters in HFD rodents.
