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Syndecans and diabetic complications: A narrative review
Yasamin Rajabloo1, Maryam Saberi-Karimian2, Sara Saffar Soflaei3
1Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
The American Journal of the Medical Sciences
|May 2, 2024
Summary
Syndecans (SDCs), a type of heparan sulfate proteoglycan, are decreased in diabetes mellitus (DM) complications. Understanding SDC molecular mechanisms is key to developing new treatments for diabetic conditions.
Area of Science:
- Biochemistry
- Molecular Biology
- Endocrinology
Background:
- Syndecans (SDCs) are heparan sulfate proteoglycans implicated in diabetic complications.
- Reduced SDC levels are observed in kidney, retina, and cardiac tissues in diabetes mellitus (DM) models.
- These reductions may contribute to albuminuria development in DM.
Purpose of the Study:
- To review the molecular mechanisms of SDCs in the development and progression of diabetic complications.
- To elucidate the complex role of SDCs and their associated molecular pathways in DM.
- To provide insights for developing novel therapeutic strategies for diabetic complications.
Main Methods:
- Literature review of studies on syndecans and diabetic complications.
- Analysis of molecular mechanisms underlying SDC function in diabetes.
- Synthesis of current evidence on SDC involvement in DM pathology.
Main Results:
- SDC levels are decreased in key organs affected by DM.
- Evidence suggests SDCs play a significant role in the pathogenesis of diabetic complications.
- Molecular mechanisms linking SDCs to DM progression are complex and require further investigation.
Conclusions:
- SDCs are critical in the pathophysiology of diabetic complications.
- Further research into SDC molecular mechanisms is essential for therapeutic development.
- Targeting SDCs may offer new avenues for preventing and treating diabetic complications.
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