Related Experiment Video
Updated: Jun 27, 2025
13:11
Optimized Analysis of DNA Methylation and Gene Expression from Small, Anatomically-defined Areas of the Brain
Published on: July 12, 2012
18.8K
The peripheral epigenome predicts white matter volume contingent on developmental stage: An ECHO study
Sophie Spencer1, Samantha A Harker1, Fatoumata Barry2
1Arizona State University.
Research Square
|May 3, 2024
Summary
Peripheral DNA methylation of myelin genes predicts white matter volume in children. This epigenetic marker
Area of Science:
- Neuroscience and Epigenetics: Investigating the interplay between DNA methylation, brain development, and white matter structure.
Background:
- Growing interest in epigenetic processes like DNA methylation as biomarkers for brain disorders.
- Significant knowledge gap exists regarding DNA methylation's correlation with individual brain structure and function variations.
- Limited understanding of how these epigenetic relationships change during critical developmental periods.
Conclusions:
- Peripheral DNA methylation of myelin-related genes serves as a predictive marker for white matter volume in children.
- Developmental stage significantly influences the DNA methylation-white matter volume association.
- Peripheral epigenetic patterns can proxy the impact of environmental factors and disorders on white matter.
More Related Videos
Related Concept Videos
01:30Biological Influences on Intelligence
95
Intelligence is often thought to be linked to brain size, but the relationship is more complex than that. While brain size does correlate modestly with some abilities, like verbal skills, the connection is weaker for others, such as spatial reasoning. Other factors, like brain structure, also play crucial roles. For instance, despite Einstein's smaller-than-average brain, his parietal cortex, which is involved in spatial reasoning, was 15% wider, suggesting that neural density might matter...
95
01:37Epigenetic Regulation
3.0K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
X-chromosome...
3.0K