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Related Experiment Video

Updated: Jun 27, 2025

Intravital Microscopy of Tumor-associated Vasculature Using Advanced Dorsal Skinfold Window Chambers on Transgenic Fluorescent Mice

Intravital Microscopy of Tumor-associated Vasculature Using Advanced Dorsal Skinfold Window Chambers on Transgenic Fluorescent Mice

Published on: January 19, 2018

Advances in Receptor-Mediated, Tumor-Targeted Drug Delivery.

Danielle E Large¹, Jonathan R Soucy¹, Jacob Hebert¹

¹Department of Chemical Engineering, Northeastern University, 360 Huntington Ave., Boston, MA 02115, USA.

Advanced Therapeutics

|May 3, 2024

Summary

Receptor-mediated drug delivery enhances cancer treatment by targeting drugs to tumors, minimizing side effects. This approach utilizes specific receptors for precise drug accumulation and improved therapeutic outcomes.

Keywords:

cancer receptor targeting targeted drug delivery therapeutic tumor accumulation

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Area of Science:

Oncology
Pharmacology
Biotechnology

Background:

Receptor-mediated drug delivery offers targeted accumulation of therapeutics in desired tissues, reducing off-target toxicity.
Overexpressed receptors on cancer cells serve as a platform for targeted drug delivery, influencing biodistribution, toxicity, and therapeutic efficacy.

Purpose of the Study:

To review promising tumor-targeted drug delivery vehicles and receptors for clinical translation.
To outline the engineering principles for targeted drug delivery vehicles, considering ligand, conjugation, and vehicle type.
To discuss recent advancements in multivalent targeting and ligand organization for enhanced tumor accumulation.

Main Methods:

Review of quantitative in vitro and in vivo data for tumor-targeted drug delivery systems.
Analysis of receptor overexpression in cancer as a targeting strategy.
Evaluation of ligand design, chemical conjugation methods, and drug delivery vehicle types.

Main Results:

Identification of drug delivery vehicles and receptors with potential for clinical translation.
Discussion of strategies for engineering targeted delivery systems.
Highlighting advances in multivalent targeting and ligand organization for improved tumor targeting.

Conclusions:

Receptor-mediated drug delivery holds significant promise for enhancing cancer therapy.
This approach can be applied to deliver chemotherapy, gene editing tools, and epigenetic drugs.
Further development in targeted delivery vehicles and strategies may revolutionize cancer treatment.