Related Experiment Video
Updated: Jun 27, 2025
08:08
Real-time Electrophysiology: Using Closed-loop Protocols to Probe Neuronal Dynamics and Beyond
Published on: June 24, 2015
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Synchronization of delayed coupled neurons with multiple synaptic connections
Masoumeh Shavikloo1, Asghar Esmaeili1, Alireza Valizadeh2,3
1Department of Physics, Faculty of Science, Urmia University, Urmia, Iran.
Cognitive Neurodynamics
|May 3, 2024
Summary
Neuronal synchronization, crucial for brain functions like memory, is impacted by synaptic connection strength and delays in multi-synaptic systems. Findings reveal how connection symmetry influences synchrony, with implications for brain disorders.
Area of Science:
- Computational Neuroscience
- Systems Neuroscience
- Neurodynamics
Background:
- Neuronal synchronization is vital for brain function, including cognition, learning, and memory.
- Cortical microcircuits feature multiple synaptic connections between neurons.
- The impact of multiple synapses on neuronal synchronization dynamics remains understudied.
Purpose of the Study:
- To investigate how synaptic connection strength and transmission delays affect synchronization in a two-neuron system with multiple synapses.
- To elucidate the role of feedforward and feedback connection symmetry in neuronal synchronization.
Main Methods:
- Analytical and computational investigation of synchronization dynamics.
- Utilized both phase oscillator and Hodgkin-Huxley (HH) models.
- Examined the influence of connection strength and transmission delays.
Main Results:
- Connection symmetry/asymmetry critically determines phase-locking stability based on connection strength and delays.
- In-phase synchrony is achieved with small and large delays in both models.
- Anti-phase synchronization is favored for median delays.
Conclusions:
- Synaptic properties significantly shape neuronal synchronization patterns.
- Findings enhance understanding of multisynaptic contacts' functional role in neuronal synchronization.
- Results may offer insights into the dynamics of brain disorders linked to pathological multisynaptic connectivity.
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