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Evaluating Virulence and Pathogenesis of Aeromonas Infection in a Caenorhabditis elegans Model
Published on: December 20, 2018
[Fatal retroperitoneal necrotizing fasciitis due to Aeromonas caviae septicaemia]
Al Hossain Al Nour1, Stefan Kothe2
1Department of internal medicine, Städtisches Klinikum Dessau, Marienstr. 10, 06844, Dessau (Roßlau), Deutschland. alhossain.alnour@gmail.com.
Abstract:
Aeromonas is well-recognized for causing diarrhea and post-traumatic wound infections. The most common Aeromonas species include Aeromonas hydrophila, Aeromonas caviae, and Aeromonas sobria. In cases of immunocompromise and malignancy, Aeromonas infections can prove fatal. Instances of deadly necrotizing fasciitis in the extremities due to Aeromonas infection have been documented. Herein, a case of previously unreported fatal retroperitoneal necrotizing fasciitis involving Aeromonas caviae in a patient with a history of gastric cancer is presented.
Insights
Aeromonas caviae can cause fatal necrotizing fasciitis, even in the retroperitoneal space. This case highlights the severe risks of Aeromonas infections in immunocompromised patients with cancer.
Area of Science:
- Microbiology
- Infectious Diseases
- Clinical Case Reports
Background:
- Aeromonas species are known pathogens causing gastrointestinal and wound infections.
- Severe Aeromonas infections, including necrotizing fasciitis, can be fatal, particularly in immunocompromised individuals.
- Gastric cancer and its treatments can increase susceptibility to opportunistic infections.
Observation:
- A previously unreported case of fatal retroperitoneal necrotizing fasciitis is presented.
- The infection was caused by Aeromonas caviae.
- The patient had a history of gastric cancer.
Findings:
- Aeromonas caviae was identified as the causative agent of retroperitoneal necrotizing fasciitis.
- The infection led to a fatal outcome despite medical intervention.
- This represents a rare and severe manifestation of Aeromonas infection.
Implications:
- This case underscores the potential for Aeromonas caviae to cause severe, life-threatening infections beyond typical presentations.
- Clinicians should maintain a high index of suspicion for invasive Aeromonas infections in immunocompromised patients, especially those with malignancy.
- Further research into the virulence factors and treatment strategies for invasive Aeromonas infections is warranted.
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