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Repair of an Upper Lip Defect

Mitchell Herold1,2, David Kent1,2, Steven Kent1,2

  • 1Skin Care Physicians of Georgia, Macon, Georgia.

Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [Et Al.]
|May 3, 2024
PubMed
Summary

No abstract available in PubMed .

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One of the common DNA damages is the chemical alteration of single bases by alkylation, oxidation, or deamination. The altered bases cause mispairing and strand breakage during replication. This type of damage causes minimal change to the DNA double helix structure and can be repaired by the base excision repair (BER) pathways. BER corrects damaged DNA sequences by removing the damaged base and restoring the original base sequence using the complementary strand as a template.
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Since the discovery of the two BER pathways, there has been a debate about how a cell chooses one pathway over the other and the factors determining this selection. Numerous in vitro experiments have pointed out multiple determinants for the sub-pathway selection. These are:
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